Kasik J W, Leuschen M P, Bolam D L, Nelson R M
Pediatrics. 1985 Aug;76(2):255-8.
Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. High myoglobin values correlated with a longer duration of oliguria in the neonatal intensive care unit population. The value of urine dipstick testing for myoglobinuria screening was also evaluated. Infants with elevated myoglobin values were more likely to have a strongly positive urine dipstick for occult blood in the first 48 hours of life. These data suggest that ischemic damage to muscle with pathologic release of myoglobin occurs in the neonatal period and that urine dipstick testing provides a reasonable screening examination for myoglobinuria.
在20名新生儿出生后的第一周内进行了系列肌红蛋白测定，以确定出生窒息是否会导致肌肉缺血性损伤，继而引起肌红蛋白的病理性释放。与对照婴儿相比，窒息婴儿的血清肌红蛋白值显著升高。在新生儿重症监护病房的人群中，高肌红蛋白值与少尿持续时间较长相关。还评估了尿试纸检测用于肌红蛋白尿筛查的价值。肌红蛋白值升高的婴儿在出生后的头48小时内更有可能尿试纸潜血检测呈强阳性。这些数据表明，新生儿期会发生肌肉缺血性损伤并伴有肌红蛋白的病理性释放，并且尿试纸检测可为肌红蛋白尿提供合理的筛查检查。
