源自[具体物质]的外泌体对油性皮肤疾病的治疗及药学潜力

Therapeutic and Pharmaceutical Potential of -Derived Exosomes for Oily Skin Disorders.

作者信息

Gong Guybin, Yun Mihae, Kwon Ohhyuk, Kim Boyong

机构信息

Department of Management of Beauty and Design, College of Design, Hansung University, Seoul 02876, Republic of Korea.

Department of Dental Hygiene, Andong Science College, Andong 36729, Republic of Korea.

出版信息

Antioxidants (Basel). 2025 Mar 19;14(3):364. doi: 10.3390/antiox14030364.

BACKGROUND

Fine dust exposure worsens oily skin by disrupting lipid metabolism and triggering oxidative inflammation. extract-induced exosomes (SBEIEs) have shown anti-inflammatory effects by suppressing reactive oxygen species (ROS) and lipid-regulating properties, making them potential therapeutic agents.

METHODS

Exosomes from fibroblasts treated with SBEIEs and PM10 were tested on macrophages, adipose-derived stem cells (ASCs), and T lymphocytes. ELISA, flow cytometry, and PCR measured cytokines and gene expression. A 10-day clinical trial evaluated skin hydration, oiliness, and inflammation.

RESULTS

SBEIEs increased IRF3 (1.6 times) and suppressed PPARγ in ASCs while enhancing lipolysis markers. Sebaceous gland activity (squalene synthase) decreased by 10%. Macrophages showed increased IRF3, IFN-β, and IL-10 (2.1 times). T cells secreted IL-4 and IL-22 (2-2.33 times). Clinically, SBEIEs improved hydration (21%), reduced oiliness (1.6 times), and decreased inflammation (2.2 times).

CONCLUSIONS

SBEIEs effectively regulate lipid metabolism, cytokines, and immune responses, showing promise to treat oily and inflamed skin caused by fine dust exposure. Further studies are needed for clinical applications.

背景

细颗粒物暴露会通过扰乱脂质代谢和引发氧化炎症来加重油性皮肤问题。大豆提取物诱导的外泌体（SBEIEs）已显示出通过抑制活性氧（ROS）具有抗炎作用以及脂质调节特性，使其成为潜在的治疗剂。

方法

用SBEIEs和PM10处理的成纤维细胞产生的外泌体在巨噬细胞、脂肪来源干细胞（ASC）和T淋巴细胞上进行测试。酶联免疫吸附测定（ELISA）、流式细胞术和聚合酶链反应（PCR）测量细胞因子和基因表达。一项为期10天的临床试验评估了皮肤水合作用、油性和炎症情况。

结果

SBEIEs使ASC中的干扰素调节因子3（IRF3）增加（1.6倍）并抑制过氧化物酶体增殖物激活受体γ（PPARγ），同时增强脂肪分解标志物。皮脂腺活性（角鲨烯合酶）降低了10%。巨噬细胞显示IRF3、干扰素-β（IFN-β）和白细胞介素-10（IL-10）增加（2.1倍）。T细胞分泌白细胞介素-4（IL-4）和白细胞介素-22（IL-22）（2 - 2.33倍）。临床上，SBEIEs改善了皮肤水合作用（21%），减少了油性（1.6倍），并减轻了炎症（2.2倍）。