韩国空气中颗粒物与特应性皮炎和慢性炎症性皮肤病的相关性研究。

Associations of particulate matter with atopic dermatitis and chronic inflammatory skin diseases in South Korea.

机构信息

Department of Dermatology, Soonchunhyang University Hospital, Seoul, South Korea.

Department of Biostatistics, Soonchunhyang University Hospital, Seoul, South Korea.

出版信息

Clin Exp Dermatol. 2022 Feb;47(2):325-334. doi: 10.1111/ced.14910. Epub 2021 Oct 24.

DOI:10.1111/ced.14910

PMID:34426985

Abstract

BACKGROUND

Particulate matter (PM) is a mixture of solid and liquid particles suspended in air, which originates from industrial plants or vehicle emissions. Although the skin is the primary body area of contact with air pollutants, the associations between PM and chronic inflammatory skin diseases has not been well established.

AIM

To investigate associations between PM and atopic dermatitis (AD) and between PM and other chronic inflammatory dermatoses, using data from the Korean Health Insurance Review and Assessment Service.

METHODS

Monthly disease statistics from the seven largest cities in South Korea (Seoul, Busan, Daegu, Incheon, Gwangju, Daejeon, Ulsan) and from Jeju Island (in total, a population of 23 288 000 for all eight areas) were included. Based on daily air pollution level and weather forecast from 2015 to 2019, multivariate negative binomial regression analysis was conducted to estimate monthly visits of AD with respect to outdoor air pollutants: coarse PM with a diameter of ≤ 10 μm (PM10) and fine PM with a diameter of ≤ 2.5 μm (PM2.5) ozone (O ), nitrogen dioxide (NO ), sulphur dioxide (SO ) and carbon monoxide (CO).

RESULTS

Increases in the levels of PM2.5, PM10, SO and CO were associated with significant increases in monthly patient visits for AD. Every 10 μg/m increase in PM2.5 and PM10 resulted in patient visit increases of 2.71% (95% CI 0.76-4.71; P < 0.01) and 2.01% (95% CI 0.92-3.11, P < 0.001), respectively, while every 1 part per billion (ppb) increase in SO and every 100 ppb increase in CO resulted in visit increases of 2.26% (95% CI 1.35-3.17; P < 0.001) and 2.86% (95% CI 1.35-4.40; P < 0.001), respectively. O and NO were not associated with increased patient visits for AD. Increases in PM2.5 and PM10 concentrations were also significantly associated with increases in patient visits for psoriasis, seborrhoeic dermatitis and rosacea.

CONCLUSION

Our data suggest that PM is associated with AD and other chronic inflammatory skin diseases.

摘要

背景

颗粒物（PM）是悬浮在空气中的固体和液体颗粒的混合物，来源于工业工厂或车辆排放。尽管皮肤是与空气污染物接触的主要身体区域，但 PM 与慢性炎症性皮肤病之间的关联尚未得到很好的证实。

目的

使用来自韩国健康保险审查和评估服务的数据，调查 PM 与特应性皮炎（AD）之间的关联，以及 PM 与其他慢性炎症性皮肤病之间的关联。

方法

纳入了韩国 7 个最大城市（首尔、釜山、大邱、仁川、光州、大田、蔚山）和济州岛（总共 8 个地区的 2328.8 万人口）的每月疾病统计数据。根据 2015 年至 2019 年的每日空气污染水平和天气预报，采用多元负二项回归分析，估计 AD 与室外空气污染物（直径≤10μm 的粗颗粒物（PM10）和直径≤2.5μm 的细颗粒物（PM2.5）、臭氧（O3）、二氧化氮（NO2）、二氧化硫（SO2）和一氧化碳（CO））每月就诊次数之间的关系。

结果

PM2.5、PM10、SO2 和 CO 水平的升高与 AD 患者每月就诊次数的显著增加有关。PM2.5 和 PM10 每增加 10μg/m，患者就诊次数分别增加 2.71%（95%CI 0.76-4.71；P<0.01）和 2.01%（95%CI 0.92-3.11，P<0.001），而 SO2 每增加 1 个十亿分之一（ppb）和 CO 每增加 100ppb，就诊次数分别增加 2.26%（95%CI 1.35-3.17；P<0.001）和 2.86%（95%CI 1.35-4.40；P<0.001）。O3 和 NO2 与 AD 患者就诊次数的增加无关。PM2.5 和 PM10 浓度的增加也与银屑病、脂溢性皮炎和酒渣鼻患者就诊次数的增加显著相关。