Danpanichkul Pojsakorn, Pang Yanfang, Auttapracha Thanida, Al Ta'ani Omar, Suenghataiphorn Thanathip, Kaewdech Apichat, Muthiah Mark D, Kim Donghee, Wijarnpreecha Karn, Singal Amit G, Yang Ju Dong
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79409, USA.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Cancers (Basel). 2025 Mar 28;17(7):1133. doi: 10.3390/cancers17071133.
: Early-onset cancer is an emerging global health concern, including in the United States. However, data on early-onset liver and intrahepatic bile duct cancer remain limited. This study aims to fill this gap by analyzing trends in early-onset liver and intrahepatic bile duct cancer in the United States over the past two decades. : This study used National Childhood Cancer Registry data to examine temporal trends in early-onset liver and intrahepatic bile duct cancer in the United States. The analysis involved estimating age-adjusted incidence rates of early-onset liver and intrahepatic bile duct cancer, stratified by histological type, ethnicity, and sex. In 2021, the age-adjusted incidence rate of early-onset liver and intrahepatic bile duct cancer was estimated at 0.53 per 100,000 population (95% Confidence Interval [CI]: 0.48-0.59). From 2001 to 2021, the age-adjusted incidence rate showed a significant annual percent change (APC) of 1.35% (95% CI: 0.87-1.83%). When stratified by sex, the age-adjusted incidence rate in females increased significantly (APC: 3.07%, 95% CI: 2.26-3.87%) while remaining stable in males. Among racial and ethnic groups, non-Hispanic American Indian and Alaska Native (AIAN) individuals had the highest age-adjusted incidence rate, recorded at 2.67 per 100,000 population (95% CI: 0.95-5.85). By histological type, hepatic carcinoma had the highest age-adjusted incidence rate, significantly increasing over time (APC: 1.47%, 95% CI: 0.96-1.99%). In contrast, the incidence rates for hepatoblastoma and unspecified hepatic tumors remained stable between 2001 and 2021. : Our study identified an increasing incidence of early-onset liver and intrahepatic bile duct cancer in the United States, primarily driven by cases in females and hepatic carcinoma.
早发性癌症正成为一个日益受到全球关注的健康问题，在美国亦是如此。然而，关于早发性肝癌和肝内胆管癌的数据仍然有限。本研究旨在通过分析过去二十年美国早发性肝癌和肝内胆管癌的趋势来填补这一空白。
本研究使用了国家儿童癌症登记处的数据，以研究美国早发性肝癌和肝内胆管癌的时间趋势。该分析包括按组织学类型、种族和性别分层，估计早发性肝癌和肝内胆管癌的年龄调整发病率。2021年，早发性肝癌和肝内胆管癌的年龄调整发病率估计为每10万人0.53例（95%置信区间[CI]：0.48 - 0.59）。从2001年到2021年，年龄调整发病率显示出显著的年百分比变化（APC）为1.35%（95%CI：0.87 - 1.83%）。按性别分层时，女性的年龄调整发病率显著上升（APC：3.07%，95%CI：2.26 - 3.87%），而男性则保持稳定。在种族和民族群体中，非西班牙裔美国印第安人和阿拉斯加原住民（AIAN）的年龄调整发病率最高，为每10万人2.67例（95%CI：0.95 - 5.85）。按组织学类型划分，肝癌的年龄调整发病率最高，且随时间显著增加（APC：1.47%，95%CI：0.96 - 1.99%）。相比之下，2001年至2021年期间，肝母细胞瘤和未明确的肝肿瘤发病率保持稳定。
我们的研究发现，美国早发性肝癌和肝内胆管癌的发病率在上升，主要由女性病例和肝癌驱动。
