Nwankwo Eugene C, Guta Amerti, Cao Scarlett S, Yang Ju Dong, Abdalla Abubaker, Taha Wesam, Larson Joseph J, Yin Jun, Gores Gregory J, Cleary Sean P, Roberts Lewis R
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.
Cancers (Basel). 2024 Jul 31;16(15):2720. doi: 10.3390/cancers16152720.
Biliary tract cancers, including cholangiocarcinoma, gallbladder, and ampulla of Vater cancers, rank second among hepatobiliary cancers, known for their poor prognoses. The United States has witnessed a notable increase in intrahepatic cholangiocarcinoma incidence. This study examines the incidence and survival outcomes of biliary tract cancers in Olmsted County, Minnesota from 1976 to 2018. Using data from the Rochester Epidemiology Project (REP), residents aged 20 and above were analyzed across four eras. Incidence rates were calculated and adjusted for age and sex, and temporal trends were assessed using Poisson regression. Intrahepatic cholangiocarcinoma exhibited a significant escalation in incidence rates over time, while gallbladder cancers showed a decline among women. Median survival times for biliary tract cancers notably improved. These findings confirm the rising incidence of intrahepatic cholangiocarcinoma and suggest improving survival rates. Nevertheless, the overall prognosis for biliary tract cancers remains very poor, emphasizing the continual need for enhanced management strategies and further research.
胆道癌，包括胆管癌、胆囊癌和壶腹癌，在肝胆癌中排名第二，预后较差。美国肝内胆管癌的发病率显著上升。本研究调查了1976年至2018年明尼苏达州奥尔姆斯特德县胆道癌的发病率和生存结果。利用罗切斯特流行病学项目（REP）的数据，对四个时期20岁及以上的居民进行了分析。计算发病率并根据年龄和性别进行调整，使用泊松回归评估时间趋势。肝内胆管癌的发病率随时间显著上升，而胆囊癌在女性中呈下降趋势。胆道癌的中位生存时间显著改善。这些发现证实了肝内胆管癌发病率的上升，并表明生存率有所提高。然而，胆道癌的总体预后仍然很差，强调持续需要加强管理策略和进一步研究。
