表现出配子特异性低甲基化的人类DNA序列。

Human DNA sequences exhibiting gamete-specific hypomethylation.

作者信息

Zhang X Y, Wang R Y, Ehrlich M

出版信息

Nucleic Acids Res. 1985 Jul 11;13(13):4837-51. doi: 10.1093/nar/13.13.4837.

DOI:10.1093/nar/13.13.4837

PMID:4022775

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321830/

Abstract

Three human DNA sequences have been cloned from DNA regions which are strikingly undermethylated in sperm, highly methylated in adult somatic tissues, and methylated to an intermediate extent in tissues of extraembryonic origin. It is proposed that some such DNA sequences may function specifically early in embryogenesis or during gametogenesis. They may be subsequently extensively methylated in the embryonic cell lineage and methylated to a lesser extent in extraembryonic tissues in order to allow embryogenesis to proceed.

摘要

从精子中显著低甲基化、成年体细胞组织中高度甲基化以及胚外起源组织中甲基化程度处于中间水平的DNA区域克隆出了三条人类DNA序列。有人提出，某些这样的DNA序列可能在胚胎发育早期或配子发生过程中具有特定功能。它们随后可能在胚胎细胞谱系中被广泛甲基化，而在胚外组织中甲基化程度较低，以便胚胎发育能够进行。