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鸡雌激素诱导型载脂蛋白VLDL II基因染色质中的核酸酶超敏位点。

Nuclease-hypersensitive sites in chromatin of the estrogen-inducible apoVLDL II gene of chicken.

作者信息

Kok K, Snippe L, Ab G, Gruber M

出版信息

Nucleic Acids Res. 1985 Jul 25;13(14):5189-202. doi: 10.1093/nar/13.14.5189.

DOI:10.1093/nar/13.14.5189
PMID:4022779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321858/
Abstract

DNAseI-hypersensitive sites were localized in apoVLDL II chromatin from chicken. In the liver two sites at 1.75 and 1.0 kb upstream from the cap-site are present before the gene is activated. After induction by estradiol a number of additional sites appear, three in the promotor region of the gene, one within the coding region and two behind the poly-A signal. These sites disappear when the expression of the gene is shut off upon estradiol withdrawal. All sites appear to be tissue-specific in that they are not found in other tissues of the rooster. However, in oviduct of the laying hen we find a hypersensitive site at 1.6 kb in front of the gene.

摘要

脱氧核糖核酸酶I超敏位点定位于鸡的载脂蛋白VLDL II染色质中。在肝脏中，在该基因被激活之前，帽位点上游1.75和1.0 kb处存在两个位点。经雌二醇诱导后，出现了一些其他位点，基因启动子区域有三个，编码区域内有一个，聚腺苷酸信号后有两个。当在撤去雌二醇后基因表达关闭时，这些位点消失。所有位点似乎都具有组织特异性，因为在公鸡的其他组织中未发现这些位点。然而，在产蛋母鸡的输卵管中，我们在该基因前1.6 kb处发现了一个超敏位点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/b7605be3c3af/nar00308-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/6eedfc97ab46/nar00308-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/aab17ea6f47d/nar00308-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/d55710ecaa37/nar00308-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/b7605be3c3af/nar00308-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/6eedfc97ab46/nar00308-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/aab17ea6f47d/nar00308-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/d55710ecaa37/nar00308-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a5d/321858/b7605be3c3af/nar00308-0193-a.jpg

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本文引用的文献

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Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I.由DNA酶I引入的珠蛋白染色质结构域中的组织特异性DNA切割。
Cell. 1980 Jun;20(2):451-60. doi: 10.1016/0092-8674(80)90631-5.
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Sequence specific cleavage of DNA by micrococcal nuclease.微球菌核酸酶对DNA的序列特异性切割。
Nucleic Acids Res. 1981 Jun 25;9(12):2643-58. doi: 10.1093/nar/9.12.2643.
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Major changes in the 5' and 3' chromatin structure of sea urchin histone genes accompany their activation and inactivation in development.海胆组蛋白基因5'和3'染色质结构的重大变化伴随着它们在发育过程中的激活和失活。
人类UBE1L基因的基因组结构。
Gene Expr. 1995;4(3):163-75.
4
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Mol Cell Biol. 1986 Jun;6(6):1886-93. doi: 10.1128/mcb.6.6.1886-1893.1986.
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Steroid hormone dependence of four DNase I-hypersensitive regions located within the 7000-bp 5'-flanking segment of the ovalbumin gene.卵清蛋白基因7000碱基对5′侧翼片段内四个脱氧核糖核酸酶I超敏感区域的类固醇激素依赖性
EMBO J. 1986 Feb;5(2):277-85. doi: 10.1002/j.1460-2075.1986.tb04210.x.
6
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Mol Cell Biol. 1987 Oct;7(10):3538-47. doi: 10.1128/mcb.7.10.3538-3547.1987.
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Nucleic Acids Res. 1987 Jun 11;15(11):4535-52. doi: 10.1093/nar/15.11.4535.
8
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Nucleic Acids Res. 1986 Nov 11;14(21):8669-80. doi: 10.1093/nar/14.21.8669.
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Nucleic Acids Res. 1983 May 11;11(9):2529-40. doi: 10.1093/nar/11.9.2529.
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Cell. 1981 Nov;27(1 Pt 2):57-64. doi: 10.1016/0092-8674(81)90360-3.
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Proc Natl Acad Sci U S A. 1983 Jun;80(11):3213-7. doi: 10.1073/pnas.80.11.3213.
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Transcriptionally active chromatin.转录活性染色质
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10
A close association between sites of DNase I hypersensitivity and sites of enhanced cleavage by micrococcal nuclease in the 5'-flanking region of the actively transcribed ovalbumin gene.在活跃转录的卵清蛋白基因5'侧翼区域，DNase I超敏位点与微球菌核酸酶增强切割位点之间存在紧密关联。
EMBO J. 1984 May;3(5):1137-44. doi: 10.1002/j.1460-2075.1984.tb01942.x.