鸡的卵黄蛋白原和载脂蛋白VLDLII基因协同表达上游的保守序列基序。
Conserved sequence motifs upstream from the co-ordinately expressed vitellogenin and apoVLDLII genes of chicken.
作者信息
van het Schip F, Strijker R, Samallo J, Gruber M, Geert A B
出版信息
Nucleic Acids Res. 1986 Nov 11;14(21):8669-80. doi: 10.1093/nar/14.21.8669.
Abstract
The vitellogenin and apoVLDLII yolk protein genes of chicken are transcribed in the liver upon estrogenization. To get information on putative regulatory elements, we compared more than 2 kb of their 5' flanking DNA sequences. Common sequence motifs were found in regions exhibiting estrogen-induced changes in chromatin structure. Stretches of alternating pyrimidines and purines of about 30-nucleotides long are present at roughly similar positions. A distinct box of sequence homology in the chicken genes also appears to be present at a similar position in front of the vitellogenin genes of Xenopus laevis, but is absent from the estrogen-responsive egg-white protein genes expressed in the oviduct. In front of the vitellogenin (position -595) and the VLDLII gene (position -548), a DNA element of about 300 base-pairs was found, which possesses structural characteristics of a mobile genetic element and bears homology to the transposon-like Vi element of Xenopus laevis.
摘要
雌激素化后，鸡的卵黄蛋白原和载脂蛋白VLDLII卵黄蛋白基因在肝脏中被转录。为了获取有关假定调控元件的信息，我们比较了它们超过2 kb的5'侧翼DNA序列。在染色质结构呈现雌激素诱导变化的区域发现了共同的序列基序。大约30个核苷酸长的嘧啶和嘌呤交替序列在大致相似的位置出现。鸡基因中一个独特的序列同源框似乎也存在于非洲爪蟾卵黄蛋白原基因前方的相似位置，但在输卵管中表达的雌激素反应性蛋清蛋白基因中不存在。在卵黄蛋白原（位置-595）和VLDLII基因（位置-548）前方，发现了一个约300个碱基对的DNA元件，它具有可移动遗传元件的结构特征，并且与非洲爪蟾的转座子样Vi元件具有同源性。
相似文献
1
Conserved sequence motifs upstream from the co-ordinately expressed vitellogenin and apoVLDLII genes of chicken.鸡的卵黄蛋白原和载脂蛋白VLDLII基因协同表达上游的保守序列基序。
Nucleic Acids Res. 1986 Nov 11;14(21):8669-80. doi: 10.1093/nar/14.21.8669.
2
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.肝脏雌激素反应性卵黄蛋白原和载脂蛋白-VLDLII基因转录起始位点之前区域的序列同源性。
Nucleic Acids Res. 1984 Nov 26;12(22):8611-26. doi: 10.1093/nar/12.22.8611.
3
Organization, sequence and nuclease hypersensitivity of repetitive elements flanking the chicken apoVLDLII gene: extended sequence similarity to elements flanking the chicken vitellogenin gene.鸡载脂蛋白VLDLII基因侧翼重复元件的组织、序列及核酸酶超敏感性：与鸡卵黄蛋白原基因侧翼元件的序列相似性扩展
Nucleic Acids Res. 1988 Jan 11;16(1):97-113. doi: 10.1093/nar/16.1.97.
4
5
Estrogen-dependent activation of the avian very low density apolipoprotein II and vitellogenin genes. Transient alterations in mRNA polyadenylation and stability early during induction.雌激素依赖性激活禽类极低密度载脂蛋白II和卵黄蛋白原基因。诱导早期mRNA聚腺苷酸化和稳定性的短暂变化。
J Mol Biol. 1988 Oct 5;203(3):555-67. doi: 10.1016/0022-2836(88)90192-1.
6
7
ApoVLDLII gene transcription in immature cockerels without estradiol stimulation.未受雌二醇刺激的未成熟公鸡中载脂蛋白VLDLII基因的转录
Comp Biochem Physiol B. 1990;97(1):55-8. doi: 10.1016/0305-0491(90)90177-u.
8
The Vi element. A transposon-like repeated DNA sequence interspersed in the vitellogenin locus of Xenopus laevis.Vi元件。一种类似转座子的重复DNA序列，散布在非洲爪蟾卵黄蛋白原基因座中。
J Mol Biol. 1985 Dec 5;186(3):491-503. doi: 10.1016/0022-2836(85)90124-x.
9
Sequence homologies within the 5' end region of the estrogen-controlled vitellogenin gene in Xenopus and chicken.非洲爪蟾和鸡中雌激素调控的卵黄蛋白原基因5'端区域内的序列同源性。
EMBO J. 1983;2(12):2271-9. doi: 10.1002/j.1460-2075.1983.tb01734.x.
10
Coordinate regulation of two estrogen-dependent genes in avian liver.鸟类肝脏中两个雌激素依赖性基因的协同调控
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4474-8. doi: 10.1073/pnas.77.8.4474.
引用本文的文献
1
Expression of Thyroid Hormone Responsive SPOT 14 Gene Is Regulated by Estrogen in Chicken (Gallus gallus).甲状腺激素反应性 SPOT14 基因的表达受雌激素在鸡（Gallus gallus）中的调控。
Sci Rep. 2017 Aug 31;7(1):10243. doi: 10.1038/s41598-017-08452-6.
2
In vivo footprinting of the estrogen-inducible vitellogenin II gene from chicken.鸡雌激素诱导的卵黄蛋白原II基因的体内足迹分析
Nucleic Acids Res. 1988 Oct 25;16(20):9663-76. doi: 10.1093/nar/16.20.9663.
3
Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.转录因子与雌激素诱导的载脂蛋白VLDL II启动子在体内的组织特异性和类固醇依赖性相互作用。
EMBO J. 1988 Sep;7(9):2757-63. doi: 10.1002/j.1460-2075.1988.tb03130.x.
4
Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene.两个功能性雌激素反应元件位于主要鸡卵黄生成素基因的上游。
Mol Cell Biol. 1988 Mar;8(3):1123-31. doi: 10.1128/mcb.8.3.1123-1131.1988.
5
The major and minor chicken vitellogenin genes are each adjacent to partially deleted pseudogene copies of the other.鸡的主要和次要卵黄蛋白原基因彼此相邻，且各自与对方部分缺失的假基因拷贝相邻。
Mol Cell Biol. 1989 Aug;9(8):3557-62. doi: 10.1128/mcb.9.8.3557-3562.1989.
6
Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo.雌激素在体内促进遍在蛋白和肝脏富集核蛋白与载脂蛋白VLDL II启动子的结合。
Nucleic Acids Res. 1991 Jan 11;19(1):33-41. doi: 10.1093/nar/19.1.33.
7
Presence of Vi-transposon-like elements in the proopiomelanocortin gene A of Xenopus laevis does not affect gene activity.非洲爪蟾促肾上腺皮质激素原基因A中Vi转座子样元件的存在不影响基因活性。
Mol Gen Genet. 1991 Dec;230(3):491-3. doi: 10.1007/BF00280307.
8
Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1.小鼠分泌型蛋白酶抑制剂p12基因的转录由发育调控的正向转录因子Sp1激活。
Mol Cell Biol. 1992 Sep;12(9):3796-806. doi: 10.1128/mcb.12.9.3796-3806.1992.
本文引用的文献
1
Translation in vivo and in vitro of mRNAs coding for vitellogenin, serum albumin and very-low-density lipoprotein II from chicken liver. A difference in translational efficiency.鸡肝中编码卵黄蛋白原、血清白蛋白和极低密度脂蛋白II的mRNA的体内和体外翻译。翻译效率的差异。
Eur J Biochem. 1981 Mar;114(3):635-41. doi: 10.1111/j.1432-1033.1981.tb05191.x.
2
Vitellogenesis and the vitellogenin gene family.卵黄生成与卵黄蛋白原基因家族
Science. 1981 Apr 17;212(4492):298-304. doi: 10.1126/science.7209528.
3
Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.雌激素可诱导鸡卵黄蛋白原基因5'端区域发生去甲基化。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4252-5. doi: 10.1073/pnas.79.14.4252.
4
Effect of the B--Z transition in poly(dG-m5dC) . poly(dG-m5dC) on nucleosome formation.聚（dG-m5dC）·聚（dG-m5dC）中B-Z转变对核小体形成的影响。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1771-5. doi: 10.1073/pnas.79.6.1771.
5
Coordinate regulation of two estrogen-dependent genes in avian liver.鸟类肝脏中两个雌激素依赖性基因的协同调控
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4474-8. doi: 10.1073/pnas.77.8.4474.
6
The nucleotide sequence of the chicken apo very low density lipoprotein II gene.鸡载脂蛋白极低密度脂蛋白II基因的核苷酸序列。
Nucleic Acids Res. 1983 May 11;11(9):2529-40. doi: 10.1093/nar/11.9.2529.
7
Independent developmental programs for two estrogen-regulated genes.两个雌激素调节基因的独立发育程序。
Science. 1984 Aug 10;225(4662):639-41. doi: 10.1126/science.6740331.
8
Identification and sequence analysis of the 5' end of the major chicken vitellogenin gene.鸡主要卵黄蛋白原基因5'端的鉴定与序列分析
Nucleic Acids Res. 1984 Jan 25;12(2):1117-35. doi: 10.1093/nar/12.2.1117.
9
Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene.雌激素受体复合物与鸡卵黄生成素II基因前含雌激素依赖性低甲基化位点区域的优先结合。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):429-33. doi: 10.1073/pnas.81.2.429.
10
Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.肝脏雌激素反应性卵黄蛋白原和载脂蛋白-VLDLII基因转录起始位点之前区域的序列同源性。
Nucleic Acids Res. 1984 Nov 26;12(22):8611-26. doi: 10.1093/nar/12.22.8611.
Zotero 插件