Olgaard K, Madsen S, Ladefoged J, Regeur L
Eur J Clin Invest. 1977 Feb;7(1):61-6. doi: 10.1111/j.1365-2362.1977.tb01571.x.
The influence of extracellular fluid volume expansion on the plasma aldosterone concentration (PAC) was investigated in five anephric and six non-nephrectomized patients on regular haemodialysis, and compared to a control group of four anephric and four non-nephrectomized patients. Plasma-renin activity, cortisol, Na+, and K+ were measured together with the PAC during the investigation. In anephric patients the PAC remained constant during the control period as well as during extracellular fluid volume expansion by infusion of 350 mmol of 20% mannitol. In the non-nephrectomized patients PAC diminished after mannitol infusion. The decline in PAC was correlated with the basal levels of PAC and the plasma renin activity. It is concluded that 5% extracellular fluid volume expansion has no direct influence on the regulation of PAC in patients without the renal renin-angiotensin system and that the regulation of PAC in anephric patients in the present investigation is probably mediated by changes in potassium and ACTH.
在五名无肾和六名未行肾切除术且定期进行血液透析的患者中，研究了细胞外液量扩张对血浆醛固酮浓度（PAC）的影响，并与由四名无肾和四名未行肾切除术患者组成的对照组进行比较。在研究期间，同时测量血浆肾素活性、皮质醇、Na⁺和K⁺以及PAC。在无肾患者中，在对照期以及通过输注350 mmol 20%甘露醇导致细胞外液量扩张期间，PAC保持恒定。在未行肾切除术的患者中，输注甘露醇后PAC降低。PAC的下降与PAC的基础水平和血浆肾素活性相关。得出的结论是，5%的细胞外液量扩张对无肾素 - 血管紧张素系统患者的PAC调节无直接影响，并且在本研究中，无肾患者的PAC调节可能由钾和促肾上腺皮质激素的变化介导。
