Saxena Ruchi, He You-Wen
Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
PLoS Biol. 2025 Apr 14;23(4):e3003109. doi: 10.1371/journal.pbio.3003109. eCollection 2025 Apr.
Regulatory T cells (Tregs) exist in distinct subsets, but key regulators of their heterogeneity remain unclear. A recent PLOS Biology study shows that the class III PI3K Vps34 acts as a master orchestrator, driving effector Treg generation and maintenance.
调节性T细胞(Tregs)以不同的亚群形式存在,但其异质性的关键调节因子仍不清楚。《公共科学图书馆·生物学》最近的一项研究表明,III类磷脂酰肌醇3激酶Vps34起着主要协调者的作用,驱动效应性调节性T细胞的产生和维持。