Asadi Asadollah, Ghahremani Rozita, Abdolmaleki Arash, Rajaei Farzad
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
Int J Reprod Biomed. 2021 Jul 27;19(6):493-504. doi: 10.18502/ijrm.v19i6.9371. eCollection 2021 Jun.
Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial membrane potential, and DNA fragmentation are apoptosis markers found in human ejaculated spermatozoa. Also, reactive oxygen species (ROS) play a vital role in the different types of male infertility. In this review, data sources including Google Scholar, Scopus, PubMed, and Science Direct were searched for publications with no particular time restriction to get a holistic and comprehensive view of the research. Apoptosis regulates the male germ cells, correct function and development from the early embryonic stages of gonadal differentiation to fertilization. In addition to maintaining a reasonable ratio between the Sertoli and germ cells, apoptosis is one of the well-known quality control mechanisms in the testis. Also, high ROS levels cause a heightened and dysregulated apoptotic response. Apoptosis is one of the well-known mechanisms of quality control in the testis. Nevertheless, increased apoptosis may have adverse effects on sperm production. Recent studies have shown that ROS and the consequent oxidative stress play a crucial role in apoptosis. This review aims to assimilate and summarize recent findings on the apoptosis in male reproduction and fertility. Also, this review discusses the update on the role of ROS in normal sperm function to guide future research in this area.
半胱天冬酶的激活、磷脂酰丝氨酸的外化、线粒体膜电位的变化以及DNA片段化是在人类射出精子中发现的凋亡标志物。此外，活性氧（ROS）在不同类型的男性不育症中起着至关重要的作用。在本综述中，对包括谷歌学术、Scopus、PubMed和科学Direct在内的数据来源进行了搜索，以获取不受特定时间限制的出版物，从而对该研究有一个全面和综合的了解。凋亡调节男性生殖细胞，从性腺分化的早期胚胎阶段到受精过程中的正常功能和发育。除了维持支持细胞和生殖细胞之间的合理比例外，凋亡是睾丸中众所周知的质量控制机制之一。此外，高ROS水平会导致增强且失调的凋亡反应。凋亡是睾丸中众所周知的质量控制机制之一。然而，凋亡增加可能对精子产生不利影响。最近的研究表明，ROS以及随之而来的氧化应激在凋亡中起关键作用。本综述旨在吸收和总结男性生殖与生育中凋亡的最新研究结果。此外，本综述讨论了ROS在正常精子功能中的作用的最新进展，以指导该领域的未来研究。
