Aune Dagfinn, Nordsletten Marie, Myklebust Tor Åge, Robsahm Trude Eid, Skålhegg Bjørn Steen, Mala Tom, Yaqub Sheraz, Saeed Usman
Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Eur J Cancer. 2025 May 15;221:115400. doi: 10.1016/j.ejca.2025.115400. Epub 2025 Apr 2.
Several studies have reported positive associations between higher body mass index (BMI) and risk of Hodgkin's lymphoma. However, the evidence is not entirely consistent. We investigated the association between BMI and Hodgkin's lymphoma in a large Norwegian cohort with up to 50 years follow-up.
The analytical dataset included 1723,692 men and women aged 16-75 years at baseline in 1963-1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations between BMI and Hodgkin's lymphoma incidence.
During 56.1 million person-years of follow-up, 1608 incident Hodgkin's lymphoma cases occurred. Compared to individuals with BMI 18.5-< 25, the HRs (95 % CIs) for those with a BMI of 15-< 18.5, 25-< 30, and ≥ 30 were 0.87 (0.59-1.27), 1.05 (0.94-1.18), and 1.61 (1.35-1.91), respectively, and 1.57 (1.30-1.90) and 1.80 (1.24-2.62) for obesity grade 1 and grade 2, respectively. A positive association was also observed per 5 kg/m increment with a HR (95 % CI) of 1.16 (1.08-1.24) overall, 1.20 (1.09-1.31) in women, and 1.08 (0.96-1.20) in men. Positive associations were also observed between obesity vs. normal weight in early adulthood (age 16-29 years) and Hodgkin's lymphoma (HR, 95 % CIs: 1.89, 1.10-3.22, p<0.0001, n = 489 cases) and between obesity and early-onset (age <50 years at diagnosis) disease (HR, 95 % CIs: 1.67, 1.01-2.78, p<0.0001, n = 393 cases).
The positive associations observed between higher BMI overall and in young adulthood and Hodgkin's lymphoma and between BMI and early-onset disease emphasize the potential role of adiposity in development of this malignancy.
多项研究报告称较高的体重指数（BMI）与霍奇金淋巴瘤风险之间存在正相关。然而，证据并不完全一致。我们在一个随访时间长达50年的大型挪威队列中调查了BMI与霍奇金淋巴瘤之间的关联。
分析数据集包括1963 - 1975年基线时年龄在16 - 75岁的1723692名男性和女性。采用多变量Cox回归分析来估计BMI与霍奇金淋巴瘤发病率之间关联的风险比（HRs）和95%置信区间（CIs）。
在5610万人年的随访期间，共发生1608例霍奇金淋巴瘤病例。与BMI为18.5 - <25的个体相比，BMI为15 - <18.5、25 - <30和≥30的个体的HRs（95% CIs）分别为0.87（0.59 - 1.27）、1.05（0.94 - 1.18）和1.61（1.35 - 1.91），肥胖1级和2级的HRs（95% CIs）分别为1.57（1.30 - 1.90）和1.80（1.24 - 2.62）。每增加5kg/m²总体上HR（95% CI）为1.16（1.08 - 1.24），女性为1.20（1.09 - 1.31），男性为1.08（0.96 - 1.20），也观察到正相关。在成年早期（16 - 29岁）肥胖与正常体重相比和霍奇金淋巴瘤之间（HR，95% CIs：1.89，1.10 - 3.22，p<0.0001，n = 489例）以及肥胖与早发（诊断时年龄<50岁）疾病之间（HR，95% CIs：1.67，1.01 - 2.78，p<0.0001，n = 393例）也观察到正相关。
总体上较高的BMI以及成年早期的BMI与霍奇金淋巴瘤之间以及BMI与早发疾病之间观察到的正相关强调了肥胖在这种恶性肿瘤发生中的潜在作用。
