Konikoff F, Halevy J, Theodor E
Postgrad Med J. 1985 Jul;61(717):595-8. doi: 10.1136/pgmj.61.717.595.
Serum creatine kinase (CK) activity was measured after intramuscular injections in 44 patients hospitalized for non-cardiac reasons. The drugs injected were: diazepam, dipyrone, metoclopramide, meperidine, pentazocine and procaine penicillin. Only 3 out of 44 patients (7%) demonstrated significant elevation of CK levels following the intramuscular injections. In these 3 patients the elevation was mainly due to a rise of the MM-isoenzyme fraction with MB levels increased in one patient. These findings do not justify the common clinical notion of regarding intramuscular injections as a frequent cause of serum CK elevation. It is concluded that high CK serum values in a patient with chest pain should always be considered with utmost suspicion, disregarding the possible effects of a previous intramuscular injection.
对44名因非心脏原因住院的患者进行肌肉注射后，测定了血清肌酸激酶（CK）活性。注射的药物有：地西泮、安乃近、甲氧氯普胺、哌替啶、喷他佐辛和普鲁卡因青霉素。44名患者中只有3名（7%）在肌肉注射后出现CK水平显著升高。在这3名患者中，升高主要是由于MM同工酶部分升高，其中1名患者的MB水平也有所增加。这些发现并不支持将肌肉注射视为血清CK升高常见原因的普遍临床观念。得出的结论是，对于胸痛患者的高CK血清值应始终高度怀疑，而不考虑先前肌肉注射可能产生的影响。
