Lefevre M E, Joel D D, Schidlovsky G
Proc Soc Exp Biol Med. 1985 Sep;179(4):522-8. doi: 10.3181/00379727-179-42133.
Conventional and germfree mice ingested a suspension of 2-micron latex particles in drinking water for a 15-day period. Number and distribution of intestinal Peyer's patches did not differ significantly in the two types of mice. Cleared Peyer's patches were compared with regard to size and particle content. The location of particles within Peyer's patch follicles of germfree mice was similar to that of conventional mice, but the latter had significantly larger follicles and greater accumulations of latex particles. Latex concentration varied with patch location. Proximal patches contained the majority of particles in germfree mice, whereas particles were most abundant in distal patches of conventional mice. The results show that particle uptake into Peyer's patches takes place even in the complete absence of bacteria in the gut.
普通小鼠和无菌小鼠在15天的时间里饮用含有2微米乳胶颗粒的悬浮液。两种类型的小鼠肠道派尔集合淋巴结的数量和分布没有显著差异。对清除后的派尔集合淋巴结的大小和颗粒含量进行了比较。无菌小鼠派尔集合淋巴结滤泡内颗粒的位置与普通小鼠相似，但普通小鼠的滤泡明显更大，乳胶颗粒的积累更多。乳胶浓度随集合淋巴结位置而变化。在无菌小鼠中，近端集合淋巴结含有大部分颗粒，而在普通小鼠的远端集合淋巴结中颗粒最为丰富。结果表明，即使肠道中完全没有细菌，派尔集合淋巴结也会摄取颗粒。
