Jepson M A, Simmons N L, Savidge T C, James P S, Hirst B H
Gastrointestinal Drug Delivery Research Centre, Medical School, University of Newcastle upon Tyne, UK.
Cell Tissue Res. 1993 Mar;271(3):399-405. doi: 10.1007/BF02913722.
The interaction between polystyrene microspheres and the follicle-associated epithelium of rabbit Peyer's patches has been examined. Microspheres bind selectively to, and are transcytosed by, membranous or microfold (M) cells within the follicle-associated epithelium. M cells are able to transport, in 45 min, approximately 10(5) microspheres of 0.46 micron diameter across the epithelium overlying each lymphoid follicle dome of rabbit Peyer's patches. The high capacity of M cells for particulate transcytosis and the subsequent delivery of these particulates to the mucosal immune system highlights the potential importance of this portal in the delivery of antigens and drugs. In addition, the selective binding and uptake of microspheres may be utilised as a functional marker in the identification and isolation of M cells.
已对聚苯乙烯微球与兔派尔集合淋巴结滤泡相关上皮之间的相互作用进行了研究。微球选择性地结合于滤泡相关上皮内的膜性或微皱（M）细胞，并被这些细胞进行转胞吞作用。M细胞能够在45分钟内将约10⁵个直径为0.46微米的微球穿过覆盖兔派尔集合淋巴结每个淋巴滤泡圆顶的上皮。M细胞对颗粒转胞吞作用的高能力以及随后将这些颗粒递送至黏膜免疫系统，突出了这个门户在抗原和药物递送中的潜在重要性。此外，微球的选择性结合和摄取可被用作鉴定和分离M细胞的功能标记。
