Liu Yangqi, Chen Zijian, Cheng Hanchang, Zheng Runzhi, Huang Weizhe
Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
J Inflamm (Lond). 2025 Apr 14;22(1):15. doi: 10.1186/s12950-025-00432-2.
Several studies have demonstrated that the pulmonary immune response is primarily facilitated by antigen-presenting cells (APCs), and that both professional and non-professional APCs contribute to overall pulmonary immunity. APCs play unique roles and mechanisms in pathogen elimination and immunomodulation. Mucosal immunity exhibits potential advantages over traditional parenteral immunity in that it stimulates immune defenses in mucosal and systemic tissues, which is important for reducing the burden of lung disease. However, obtaining a comprehensive understanding of the crosstalk between mucosal immunity and APC in the context of various lung diseases remains challenging. This mini-review aimed to elucidate the mechanisms of novel mucosal immunity, targeting APC action during lung infections, allergies, and malignant tumorigenesis. This minreview provides important insights into more effective therapeutic approaches for various lung diseases.
多项研究表明，肺部免疫反应主要由抗原呈递细胞（APC）介导，专业和非专业APC均对整体肺部免疫有贡献。APC在病原体清除和免疫调节中发挥着独特的作用和机制。黏膜免疫相对于传统的肠胃外免疫具有潜在优势，因为它能刺激黏膜和全身组织中的免疫防御，这对于减轻肺部疾病负担很重要。然而，在各种肺部疾病背景下全面了解黏膜免疫与APC之间的相互作用仍然具有挑战性。本综述旨在阐明新型黏膜免疫的机制，针对肺部感染、过敏和恶性肿瘤发生过程中的APC作用。本综述为各种肺部疾病更有效的治疗方法提供了重要见解。
