Osorio-Valencia Sara, Zhou Bisheng
Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Biomedicines. 2024 Mar 13;12(3):632. doi: 10.3390/biomedicines12030632.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present life-threatening conditions characterized by inflammation and endothelial injury, leading to increased vascular permeability and lung edema. Key players in the pathogenesis and resolution of ALI are macrophages (Mφs) and endothelial cells (ECs). The crosstalk between these two cell types has emerged as a significant focus for potential therapeutic interventions in ALI. This review provides a brief overview of the roles of Mφs and ECs and their interplay in ALI/ARDS. Moreover, it highlights the significance of investigating perivascular macrophages (PVMs) and immunomodulatory endothelial cells (IMECs) as crucial participants in the Mφ-EC crosstalk. This sheds light on the pathogenesis of ALI and paves the way for innovative treatment approaches.
急性肺损伤（ALI）及其严重形式急性呼吸窘迫综合征（ARDS）是危及生命的病症，其特征为炎症和内皮损伤，导致血管通透性增加和肺水肿。ALI发病机制及转归中的关键因素是巨噬细胞（Mφs）和内皮细胞（ECs）。这两种细胞类型之间的相互作用已成为ALI潜在治疗干预的重要焦点。本综述简要概述了Mφs和ECs在ALI/ARDS中的作用及其相互作用。此外，它强调了研究血管周围巨噬细胞（PVMs）和免疫调节内皮细胞（IMECs）作为Mφ-EC相互作用关键参与者的重要性。这为ALI的发病机制提供了线索，并为创新治疗方法铺平了道路。
