Dai Fang, Wu Zijian, Qin Shuai, Wu Fang, Wang Mingqiang, Liu Xiangxiu, Liu Fen
Department of Endocrinology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China.
Department of Brain surgery, The Second People's Hospital of Guizhou Province, Guiyang, People's Republic of China.
Int J Womens Health. 2025 Apr 10;17:1019-1026. doi: 10.2147/IJWH.S517997. eCollection 2025.
To analyze the influence of subclinical hypothyroidism (SCH) on endocrine and metabolic characteristics in patients with polycystic ovary syndrome (PCOS).
A total of 198 cases of PCOS patients admitted to our hospital from January 2022 to December 2023 were selected for the study. According to the presence or absence of SCH, patients were divided into the SCH group (n = 40) and the non-SCH group (n = 158). Differences in demographic characteristics, thyroid hormones, sex hormones, and glucose and lipid metabolism were analyzed between the two groups. Additionally, the correlation between SCH and various endocrine and metabolic indicators in PCOS patients was assessed.
There was no statistically significant difference in demographic characteristics between the two groups ( > 0.05). Compared to the non-SCH group, the SCH group had significantly higher levels of serum luteinizing hormone (LH), prolactin (PRL), triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) ( < 0.05), Conversely, the SCH group had significantly lower levels of serum follicle-stimulating hormone (FSH), estradiol (E2), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) ( < 0.05). Correlation analysis indicated that LH, FSH, E2, PRL, TSH, TG, TC, FINS, HOMA-IR were positively correlated with PCOS complicated by SCH, while FT3, FT4 were negatively correlated.
SCH in PCOS patients is associated with endocrine and metabolic dysfunction, primarily affecting thyroid hormone levels, sex hormones, and glucose and lipid metabolism. Assessing thyroid function is essential for the comprehensive evaluation and management of PCOS patients.
分析亚临床甲状腺功能减退症（SCH）对多囊卵巢综合征（PCOS）患者内分泌及代谢特征的影响。
选取2022年1月至2023年12月我院收治的198例PCOS患者进行研究。根据是否存在SCH，将患者分为SCH组（n = 40）和非SCH组（n = 158）。分析两组患者在人口统计学特征、甲状腺激素、性激素以及糖脂代谢方面的差异。此外，评估PCOS患者中SCH与各项内分泌及代谢指标之间的相关性。
两组患者在人口统计学特征方面无统计学显著差异（> 0.05）。与非SCH组相比，SCH组血清促黄体生成素（LH）、催乳素（PRL）、甘油三酯（TG）、总胆固醇（TC）、空腹胰岛素（FINS）及胰岛素抵抗稳态模型评估（HOMA-IR）水平显著更高（< 0.05）。相反，SCH组血清促卵泡生成素（FSH）、雌二醇（E2）、促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）及游离甲状腺素（FT4）水平显著更低（< 0.05）。相关性分析表明，LH、FSH、E2、PRL、TSH、TG、TC、FINS、HOMA-IR与合并SCH的PCOS呈正相关，而FT3、FT4与之呈负相关。
PCOS患者中的SCH与内分泌及代谢功能障碍相关，主要影响甲状腺激素水平、性激素以及糖脂代谢。评估甲状腺功能对于PCOS患者的综合评估及管理至关重要。
