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靶向ST2 KL104型的裂解性噬菌体phi1_092060的基因组序列

Genome sequence of a lytic phage phi1_092060 targeting ST2 KL104-type .

作者信息

Wei Li, Qin Jiayuan, Feng Yu, Zong Zhiyong

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Microbiol Resour Announc. 2025 May 8;14(5):e0015625. doi: 10.1128/mra.00156-25. Epub 2025 Apr 15.

DOI:10.1128/mra.00156-25
PMID:40231663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12060679/
Abstract

We describe the genome of a lytic phage isolated from sewage, which is capable of lysing ST2 KL104-type carbapenem-resistant strains. The genome is 167,208 bp in length, has a guanine-cytosine (GC) content of 37%, and includes 266 protein-coding sequences and five tRNAs.

摘要

我们描述了一种从污水中分离出的裂解性噬菌体的基因组，该噬菌体能够裂解ST2 KL104型耐碳青霉烯菌株。该基因组长度为167,208 bp，鸟嘌呤-胞嘧啶（GC）含量为37%，包含266个蛋白质编码序列和5个tRNA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ef0/12060679/788f72454d83/mra.00156-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ef0/12060679/788f72454d83/mra.00156-25.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ef0/12060679/788f72454d83/mra.00156-25.f001.jpg

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本文引用的文献

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BMC Microbiol. 2025 Jan 13;25(1):17. doi: 10.1186/s12866-024-03736-0.
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Treatment Approaches for Carbapenem-Resistant Acinetobacter baumannii Infections.耐碳青霉烯鲍曼不动杆菌感染的治疗方法
Drugs. 2025 Jan;85(1):21-40. doi: 10.1007/s40265-024-02104-6. Epub 2024 Nov 28.
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VFDB 2025: an integrated resource for exploring anti-virulence compounds.VFDB 2025：一个用于探索抗毒力化合物的综合资源库。
Nucleic Acids Res. 2025 Jan 6;53(D1):D871-D877. doi: 10.1093/nar/gkae968.
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Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens.基因组监测作为一种可扩展的框架，用于针对抗生素耐药病原体的精准噬菌体治疗。
Cell. 2024 Oct 17;187(21):5901-5918.e28. doi: 10.1016/j.cell.2024.09.009. Epub 2024 Sep 26.
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