艾滋病毒感染儿童开始接受抗逆转录病毒治疗时CD4测量及免疫抑制的全球趋势
Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV.
作者信息
Patten Gabriela, Malateste Karen, Bolton Moore Carolyn, Sipambo Nosisa, Mokone Limpho, Anderegg Nanina, Wools-Kaloustian Kara, Michael Denna, Odhiambo Francesca, Kasozi Charles, Desmonde Sophie, Amorissani-Folquet Madeleine, Leroy Valériane, Kumara Wati Dewi, Nallusamy Revathy, Kinikar Aarti, Quy Du Tuan, Yotebieng Marcel, Ebasone Peter Vanes, Lelo Patricia, Pinto Jorge, Rouzier Vanessa, Machado Daisy Maria, Haw Nel Jason, Ford Nathan
机构信息
From the Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa.
University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, Bordeaux, France.
出版信息
Pediatr Infect Dis J. 2025 Apr 4;44(9):873-875. doi: 10.1097/INF.0000000000004819.
Eligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
抗逆转录病毒疗法的资格不再基于免疫标准。在2005年至2021年期间的一个由97453名儿童组成的全球队列中，我们观察到CD4检测率大幅下降，5岁以下儿童从51%降至12%，5至14岁儿童从74%降至20%。缺乏CD4检测可能会对严重免疫抑制的临床护理和监测产生负面影响。
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