Hagos Hindeya Hailu, Gebremichael Yemane Leake, Reta Birhanu Kassie, Woldu Tiegist Bahta, Yohala Hadush Fitsum, Kidanu Gebreyohans Tesfay
Aksum University, College of Health Science, Department of Pediatrics and Child Health, Aksum, Ethiopia.
Aksum University, College of Health Science, Department of Pediatrics and Child Health, Aksum, Ethiopia.
Int J Surg Case Rep. 2025 May;130:111298. doi: 10.1016/j.ijscr.2025.111298. Epub 2025 Apr 14.
Cholecystitis is inflammatory condition of the gallbladder, usually associated with gallstones. It has serious medical complications if left untreated. Both calculous and acalculous cholecystitis are relatively well defined in older children. However, acute acalculous cholecystitis in neonates is exceedingly rare entity and is not well defined in the literature.
We reported a 3-day old, male neonate, weighing 3100 g, born to 26-year-old para II mother at term gestation who brought with the complaint of repeated vomiting of every breast fed for two days. On examination he had deranged vital signs. Abdominal Ultrasound showed features of acute cholecystitis. He had received intravenous fluid and first line antibiotics, improved and discharged after 7 days of hospital stay.
Acute acalculous cholecystitis is the inflammation of the gallbladder. In neonates it commonly occurs in association with sepsis, prematurity, medications and bacterial infections (Escherichia coli) among others. It is also associated with congenital anomalies. Unlike older children neonates present more with variable clinical manifestations and thus the diagnosis may be challenging based on clinical presentation. Moreover, the diagnosis of acalculous cholecystitis is usually obtained through abdominal ultrasonography. The management of acute acalculous neonatal cholecystitis can be conservative and operative.
Even though it is rare, NAC shall be considered in the list of differentials in neonates who presented with features of sepsis and acute abdomen, particularly those with intractable vomiting.
胆囊炎是胆囊的炎症性疾病,通常与胆结石有关。如果不治疗,会引发严重的医学并发症。在大龄儿童中,结石性胆囊炎和非结石性胆囊炎都有相对明确的定义。然而,新生儿急性非结石性胆囊炎是一种极其罕见的病症,在文献中尚无明确界定。
我们报告了一名3日龄男婴,体重3100克,其母亲26岁,足月妊娠,经产二胎。患儿因两天来每次母乳喂养后反复呕吐前来就诊。检查发现其生命体征紊乱。腹部超声显示急性胆囊炎的特征。患儿接受了静脉输液和一线抗生素治疗,住院7天后病情好转出院。
急性非结石性胆囊炎是胆囊的炎症。在新生儿中,它通常与败血症、早产、药物和细菌感染(大肠杆菌)等有关。它也与先天性畸形有关。与大龄儿童不同,新生儿的临床表现更为多样,因此基于临床表现进行诊断可能具有挑战性。此外,非结石性胆囊炎的诊断通常通过腹部超声检查获得。新生儿急性非结石性胆囊炎的治疗可以是保守治疗和手术治疗。
尽管罕见,但对于出现败血症和急腹症特征的新生儿,尤其是那些伴有顽固性呕吐的新生儿,在鉴别诊断时应考虑到新生儿急性非结石性胆囊炎。