Qin Yu, Ye Jing-Jing, Wu Xu-Nan, Xia Yue, Li Hao-Xiang, Yang Ling, Deng Xia, Yuan Guo-Yue
Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, China.
Diabetol Metab Syndr. 2025 Apr 15;17(1):129. doi: 10.1186/s13098-025-01685-w.
The purpose of this study is to investigate the relationship between the weight-adjusted waist index (WWI) and the incidence of carotid atherosclerotic plaque in patients with type 2 diabetes (T2DM) in the Chinese population.
A retrospective cross sectional analysis was conducted on data from 801 adult patients from May 2018 to January 2024. Spearman's correlation analysis was used to determine the correlation between WWI and carotid atherosclerotic plaque and analyzed the factors influencing carotid atherosclerotic plaque through binary logistic regression. Additionally, the area under the receiver operating characteristic (ROC) curve (AUC) was calculated to analyze the optimal cut-off point for WWI to predict carotid atherosclerotic plaque.
Compared with the non-carotid atherosclerotic plaque group, the incidence of hypertension, systolic blood pressure, in the carotid atherosclerotic plaque group were higher than in the non-carotid plaque group(P < 0.05). Correlation analysis showed that WWI was positively correlated with carotid atherosclerotic plaque (r = 0.263)(P < 0.05). Binary logistic regression analysis showed that WWI was an independent risk factor for carotid atherosclerotic plaque in patients with T2DM. The ROC curve analysis for the WWI yielded an AUC of 0.65 (95% CI = 0.611-0.69, P < 0.05) for predicting the presence of carotid atherosclerotic plaque.
WWI was independently associated with the occurrence of carotid atherosclerotic plaque in patients with T2DM. Given its simplicity and widespread use, WWI emerges as a novel and practical predictor for assessing the risk of developing carotid atherosclerotic plaque in Chinese patients with T2DM.
本研究旨在探讨中国人群中2型糖尿病（T2DM）患者的体重调整腰围指数（WWI）与颈动脉粥样硬化斑块发生率之间的关系。
对2018年5月至2024年1月期间801例成年患者的数据进行回顾性横断面分析。采用Spearman相关性分析确定WWI与颈动脉粥样硬化斑块之间的相关性，并通过二元逻辑回归分析影响颈动脉粥样硬化斑块的因素。此外，计算受试者工作特征（ROC）曲线下面积（AUC），以分析WWI预测颈动脉粥样硬化斑块的最佳切点。
与非颈动脉粥样硬化斑块组相比，颈动脉粥样硬化斑块组的高血压发病率、收缩压均高于非颈动脉斑块组（P＜0.05）。相关性分析显示，WWI与颈动脉粥样硬化斑块呈正相关（r = 0.263）（P＜0.05）。二元逻辑回归分析表明，WWI是T2DM患者颈动脉粥样硬化斑块的独立危险因素。WWI的ROC曲线分析得出预测颈动脉粥样硬化斑块存在的AUC为0.65（95%CI = 0.611 - 0.69，P＜0.05）。
WWI与T2DM患者颈动脉粥样硬化斑块的发生独立相关。鉴于其简单性和广泛应用，WWI成为评估中国T2DM患者发生颈动脉粥样硬化斑块风险的一种新颖且实用的预测指标。
