Rune S J, Worning H
Scand J Gastroenterol. 1985 May;20(4):525-9. doi: 10.3109/00365528509089691.
A secretin-cholecystokinin test was performed in 103 patients, representing both normal and reduced exocrine pancreatic function. The duodenum was intubated with a triple-lumen tube. The gastric and duodenal contents were aspirated separately and sampled in 10-min periods. An inert, water-soluble marker (58Co-vitamin B12 dissolved in isotonic saline) was infused at a constant rate into the duodenum. Exocrine pancreatic secretion was stimulated by continuous intravenous infusion of secretin for 60 min and a combination of secretin and cholecystokinin for another 60 min. The total recovery of the infused marker was 80%. The concentration of marker in the aspirate did not vary significantly between consecutive 10-min periods during the last 20 min of the secretin stimulation period or during the last 50 min of the combined secretin-cholecystokinin stimulation period, indicating a steady secretion rate into the duodenum. By means of the marker concentrations in the aspirate, the duodenal volumes were calculated and found to vary significantly less than the aspirated volumes. This finding demonstrates that the duodenal volume calculated from the recovery of an inert marker is a closer estimate of the true volume than that obtained by the usual aspiration technique without a volume indicator.
对103例患者进行了促胰液素-胆囊收缩素试验，这些患者代表了外分泌胰腺功能正常和减退的情况。用三腔管对十二指肠进行插管。分别抽吸胃和十二指肠内容物，并每隔10分钟取样。将一种惰性水溶性标记物（溶解于等渗盐水中的58钴维生素B12）以恒定速率注入十二指肠。通过持续静脉输注促胰液素60分钟以及促胰液素和胆囊收缩素联合输注60分钟来刺激外分泌胰腺分泌。注入标记物的总回收率为80%。在促胰液素刺激期的最后20分钟或促胰液素-胆囊收缩素联合刺激期的最后50分钟内，连续10分钟期间抽吸物中标记物的浓度没有显著变化，这表明向十二指肠的分泌速率稳定。通过抽吸物中的标记物浓度计算十二指肠容积，发现其变化明显小于抽吸容积。这一发现表明，与没有容积指示剂的常规抽吸技术相比，根据惰性标记物回收率计算出的十二指肠容积更接近真实容积。
