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生长抑素对人注射促胰液素和缩胆囊素-促胰酶素后引起的胰液和酶分泌及胆囊收缩的抑制作用（作者译）

[Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].

作者信息

Creutzfeldt W, Lankisch P G, Fölsch U R

出版信息

Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8.

PMID:1126301
Abstract

Somatostatin (200 mug/h) was administered to five healthy volunteers after submaximal stimulation of exocrine pancreatic secretion with 0.33 KU secretin or cholecystokinin-pancreozymin, given intravenously. In all instances there was a significant reduction in duodenal secretory volume after secretin, without any change in HCO3- concentration. Stimulation of enzyme secretion by cholecystokinin-pancreozymin was significantly inhibited and gallbladder contraction abolished.

摘要

在用0.33KU促胰液素或胰泌素-缩胆囊素静脉注射对5名健康志愿者进行胰腺外分泌亚最大刺激后，给予生长抑素（200微克/小时）。在所有情况下，注射促胰液素后十二指肠分泌量显著减少，而HCO3-浓度无任何变化。胰泌素-缩胆囊素对酶分泌的刺激被显著抑制，胆囊收缩消失。

相似文献

1
[Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].生长抑素对人注射促胰液素和缩胆囊素-促胰酶素后引起的胰液和酶分泌及胆囊收缩的抑制作用（作者译）
Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8.
2
Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction induced by secretin, cholecystokinin-pancreozymin and carbachol administration.生长抑素对由促胰液素、胆囊收缩素-促胰酶素及卡巴胆碱给药所诱导的胰液和酶分泌以及胆囊收缩的抑制作用。
Z Gastroenterol Verh. 1976(10):51-5.
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[Behavior of secretin-pancreozymin-stimulated pancreatic secretion, gallbladder contraction and choleresis after somatostatin administration].[注射生长抑素后促胰液素-胰酶泌素刺激的胰腺分泌、胆囊收缩及胆汁分泌的变化]
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[Pancreatic secretion in man after stimulation with cholecystokinin-pancreozymin, secretin and bile. Methods and normal ranges (author's transl)].[人经胆囊收缩素-促胰酶素、促胰液素和胆汁刺激后的胰腺分泌。方法及正常范围（作者译）]
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Inhibition of cholecystokinin-stimulated pancreaticobiliary output in man by the cholecystokinin receptor antagonist MK-329.胆囊收缩素受体拮抗剂MK-329对人胆囊收缩素刺激的胰胆分泌的抑制作用。
Scand J Gastroenterol. 1991 Jun;26(6):627-37. doi: 10.3109/00365529109043637.
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Klin Wochenschr. 1973 Sep 15;51(18):921-5. doi: 10.1007/BF01468067.
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Effect of somatostatin on exocrine pancreatic secretion stimulated by pancreozymin-secretin or by a test meal in the dog.生长抑素对胰泌素-促胰液素或犬试餐刺激的胰腺外分泌的影响。
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The release of enterokinase following secretin and cholecystokinin-pancreozymin in man.人在分泌素和缩胆囊素-促胰酶素作用下肠激酶的释放
Scand J Gastroenterol. 1979;14(8):1001-7.
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Reduced inhibitory effect of somatostatin on the exocrine function of the pancreas and on serum insulin (IRI) levels in chronic relapsing pancreatitis.生长抑素对慢性复发性胰腺炎胰腺外分泌功能及血清胰岛素（IRI）水平的抑制作用减弱。
Horm Metab Res. 1984 Dec;16 Suppl 1:155-9. doi: 10.1055/s-2007-1014922.
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Stimulation of pancreatic secretion of enzymes by acute hypercalcaemia in man.急性高钙血症对人体胰腺酶分泌的刺激作用。
Eur J Clin Invest. 1973 Mar;3(2):98-104. doi: 10.1111/j.1365-2362.1973.tb00335.x.

引用本文的文献

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European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.欧洲胰腺外分泌功能不全诊断与治疗指南：UEG、EPC、EDS、ESPEN、ESPGHAN、ESDO和ESPCG基于证据的建议。
United European Gastroenterol J. 2025 Feb;13(1):125-172. doi: 10.1002/ueg2.12674. Epub 2024 Dec 5.
2
Cholescintigraphic study of effect of somatostatin analog, octreotide, on bile secretion and gallbladder emptying in normal subjects.生长抑素类似物奥曲肽对正常受试者胆汁分泌和胆囊排空影响的胆闪烁造影研究。
Dig Dis Sci. 1993 Sep;38(9):1718-21. doi: 10.1007/BF01303183.
3
Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegaly. A prospective study.
奥曲肽对肢端肥大症患者胆汁脂质成分及胆固醇结晶形成的影响。一项前瞻性研究。
Dig Dis Sci. 1994 Nov;39(11):2384-8. doi: 10.1007/BF02087655.
4
The milieu interieur and the islets of Langerhans.内环境与胰岛
Diabetologia. 1981;20(1):1-11. doi: 10.1007/BF00253809.
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Gall-bladder water and electrolyte transport and its regulation.胆囊水和电解质转运及其调节
Gut. 1983 Jun;24(6):579-93. doi: 10.1136/gut.24.6.579.
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A small dose of somatostatin inhibits the secretin stimulated secretion of bicarbonate, amylase, and chymotrypsin in man.小剂量的生长抑素可抑制人在促胰液素刺激下的碳酸氢盐、淀粉酶和胰凝乳蛋白酶的分泌。
J Endocrinol Invest. 1980 Jul-Sep;3(3):279-82. doi: 10.1007/BF03348276.
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Somatostatinoma syndrome. Clinical, morphological and metabolic features and therapeutic aspects.生长抑素瘤综合征。临床、形态学、代谢特征及治疗方面
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Somatostatin and the intestinal transport of glucose and other nutrients in the anaesthetised rat.生长抑素与麻醉大鼠体内葡萄糖及其他营养物质的肠道转运
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Effect of somatostatin 14 on pure human pancreatic secretion.生长抑素14对人纯胰腺分泌的影响。
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