Arica Gorkem, Davutoglu Ebru Alici, Buldum Dilek, Kucuksuleymanoglu Dogu, Najmeddin Samira, Madazli Riza
Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
J Clin Ultrasound. 2025 Jul-Aug;53(6):1288-1295. doi: 10.1002/jcu.24008. Epub 2025 Apr 16.
To construct nomograms for both sides of the fetal fornix-hippocampus complex (FHC) length and hippocampus height between 18 + 0 and 23 + 6 weeks of gestation using two-dimensional sonography. Additionally, we evaluated the effects of laterality, fetal sex, and maternal iron deficiency anemia on these measurements.
This was a prospective cross-sectional study of 223 singleton pregnancies between 18 + 0 and 23 + 6 weeks of gestation. The FHC length and hippocampus height were measured on both sides in the parasagittal cranial plane of the fetus by 2D ultrasonography. Measurements from 30 women with iron deficiency anemia, out of 223 patients, were compared to those of normal controls.
Nomograms for FHC length and hippocampus height were constructed, showing a strong correlation with gestational age. No significant differences were found between the right and left side FHC lengths or hippocampus heights (p > 0.05), nor between male and female fetuses (p > 0.05). The FHC lengths (p > 0.05) and hippocampus heights (p > 0.05) of fetuses in anemic and non-anemic pregnancies also showed no significant differences.
2D ultrasound morphology of the fetal hippocampus and fornix during the second trimester is not significantly different between pregnancies with iron deficiency anemia and nonanemic women.
使用二维超声构建妊娠18⁺⁰至23⁺⁶周胎儿穹窿 - 海马复合体（FHC）长度和海马高度两侧的列线图。此外，我们评估了侧别、胎儿性别和母体缺铁性贫血对这些测量值的影响。
这是一项对223例妊娠18⁺⁰至23⁺⁶周单胎妊娠的前瞻性横断面研究。通过二维超声在胎儿矢状旁颅平面两侧测量FHC长度和海马高度。将223例患者中30例缺铁性贫血女性的测量值与正常对照组进行比较。
构建了FHC长度和海马高度的列线图，显示与孕周有很强的相关性。左右两侧FHC长度或海马高度之间未发现显著差异（p>0.05），男性和女性胎儿之间也未发现显著差异（p>0.05）。贫血和非贫血妊娠胎儿的FHC长度（p>0.05）和海马高度（p>0.05）也未显示出显著差异。
妊娠中期胎儿海马和穹窿的二维超声形态在缺铁性贫血妊娠和非贫血女性之间没有显著差异。
