Basu Biswajit, Dutta Srabona, Rahaman Monosiz, Dutta Swarnali, Ansari Mohd Nazam, Prajapati Bhupendra G, Dutta Ayon, Ghosh Sourav
School of Health and Medical Sciences, Adamas University, Kolkata, West Bengal, India.
Department of Pharmacology, Birla Institute of Technology Mesra, Ranchi, Jharkhand, India.
J Biomed Mater Res B Appl Biomater. 2025 May;113(5):e35582. doi: 10.1002/jbm.b.35582.
Nanoemulsions are tiny mixtures of water and oil stabilized by surfactants, and they have become increasingly popular across various industries, including medicine. With droplet sizes in the nanometer scale, these mixtures are both compact and effective. This discussion explores the potential of polysaccharide-based nanotechnology as an innovative approach to drug delivery. Nanoemulsions offer several benefits, such as enhanced drug solubility and bioavailability, which are crucial for drugs that poorly dissolve in water. The incorporation of natural polysaccharides as emulsifiers in these nanoemulsions ensures their biocompatibility and safety within the body. Additionally, nanoemulsions can facilitate a sustained release of medications, allowing for gradual drug release over an extended period. This controlled release can be achieved through the careful selection and formulation of polysaccharides. This review addresses the methods for producing polysaccharide-based nanoemulsions and examines their physical and chemical properties. It highlights the influence of polysaccharide molecular weight and structure on the stability of nanoemulsions and the effectiveness of drug encapsulation. By understanding these factors, researchers can develop more efficient and safe drug delivery systems utilizing nanoemulsions. Additionally, the present article provides explicit and thorough information about the use of NPLS-based nano-carriers encapsulating a number of drugs designed to treat a variety of conditions, such as diabetes, cancer, HIV, malaria, cardiovascular and respiratory diseases, and skin diseases. For this reason, it is very important to review the most recent developments in polysaccharide-based nano-biocarriers in drug delivery and their application in the treatment of diseases. In this work, we concentrated on the preparation of polysaccharide-based nano-biocarriers, commonly used polysaccharides for the preparation of nano-biocarriers, and drugs loaded on polysaccharide-based nano-biocarriers to treat diseases. In the near future, polysaccharide-based nano-biocarriers will be used more and more frequently in drug delivery and disease treatment.
纳米乳剂是由表面活性剂稳定的水和油的微小混合物，在包括医学在内的各个行业中越来越受欢迎。这些混合物的液滴尺寸在纳米尺度，既紧凑又有效。本讨论探讨了基于多糖的纳米技术作为一种创新的药物递送方法的潜力。纳米乳剂具有多种益处，例如提高药物溶解度和生物利用度，这对于难溶于水的药物至关重要。在这些纳米乳剂中加入天然多糖作为乳化剂可确保其在体内的生物相容性和安全性。此外，纳米乳剂可以促进药物的持续释放，使药物在较长时间内逐渐释放。这种控释可以通过仔细选择和配制多糖来实现。本综述阐述了制备基于多糖的纳米乳剂的方法，并研究了它们的物理和化学性质。它强调了多糖分子量和结构对纳米乳剂稳定性和药物包封有效性的影响。通过了解这些因素，研究人员可以开发出利用纳米乳剂的更高效、更安全的药物递送系统。此外，本文还提供了关于使用基于多糖的纳米载体包封多种旨在治疗各种病症（如糖尿病、癌症、艾滋病毒、疟疾、心血管和呼吸系统疾病以及皮肤病）的药物的明确而全面的信息。因此，回顾基于多糖的纳米生物载体在药物递送方面的最新进展及其在疾病治疗中的应用非常重要。在这项工作中，我们专注于基于多糖的纳米生物载体的制备、用于制备纳米生物载体的常用多糖以及负载在基于多糖的纳米生物载体上用于治疗疾病的药物。在不久的将来，基于多糖的纳米生物载体将越来越频繁地用于药物递送和疾病治疗。
