Sulaiman Usman, Vaughan Reagan, Siegel Paul, Liu Dongmin, Gilbert Elizabeth, Cline Mark
School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Domest Anim Endocrinol. 2025 Jul;92:106942. doi: 10.1016/j.domaniend.2025.106942. Epub 2025 Apr 2.
Oleuropein, a phenolic compound derived from olives, was investigated for its effects on the adipose tissue physiology of broiler chickens during the initial 10 days post-hatch. We hypothesized that oleuropein could modulate the adipose tissue of the chicken due to its known bioactive properties. Sixty-eight day-of-hatch Cobb-Hubbard broilers were randomly divided into treatment groups receiving different amounts of oleuropein (0, 125, 250, or 500 mg/kg of commercial starter diet). Diets were fed ad-lib and on day 10 post-hatch, blood and adipose tissue samples (abdominal and subcutaneous) were collected from 12 broilers in each group. Plasma was collected to measure non-esterified fatty acids (NEFA) concentrations. The mRNA levels of key regulators of adipogenesis and lipolysis were assessed by real-time PCR. At day 10, body weights were lower in the 125 and 250-dose groups. In both adipose tissue depots, lipolytic enzyme adipose triglyceride lipase (ATGL) mRNA was higher in the 125-dose group compared to other groups. Diacylglycerol O-acyltransferase 2 (DGAT2) and peroxisome proliferator-activated receptor γ (PPARγ) were lower in the 125-dose group relative to other groups. Plasma NEFAs were greater in the 125-dose group than in the other groups. This suggests that oleuropein has pro-lipolytic and anti-adipogenic properties and may provide a means to reduce excessive adipose tissue accumulation in broilers.
橄榄苦苷是一种从橄榄中提取的酚类化合物，研究人员对其在孵化后最初10天内对肉鸡脂肪组织生理的影响进行了研究。我们假设，由于橄榄苦苷已知的生物活性特性，它可以调节鸡的脂肪组织。68只刚孵化的科宝-哈伯德肉鸡被随机分为不同处理组，分别接受不同剂量的橄榄苦苷（0、125、250或500毫克/千克的商业育雏日粮）。自由采食这些日粮，在孵化后第10天，从每组12只肉鸡中采集血液和脂肪组织样本（腹部和皮下）。收集血浆以测量非酯化脂肪酸（NEFA）浓度。通过实时聚合酶链反应评估脂肪生成和脂肪分解关键调节因子的mRNA水平。在第10天，125毫克/千克和250毫克/千克剂量组的体重较低。在两个脂肪组织库中，125毫克/千克剂量组的脂肪分解酶脂肪甘油三酯脂肪酶（ATGL）的mRNA水平高于其他组。相对于其他组，125毫克/千克剂量组的二酰甘油O-酰基转移酶2（DGAT2）和过氧化物酶体增殖物激活受体γ（PPARγ）较低。125毫克/千克剂量组的血浆NEFAs含量高于其他组。这表明橄榄苦苷具有促脂肪分解和抗脂肪生成特性，可能为减少肉鸡过多脂肪组织积累提供一种方法。
