Tatli Emel
Department of Nephrology, Gaziosmanpasa City Hospital, Istanbul, Turkey.
Cir Cir. 2025;93(1):41-46. doi: 10.24875/CIRU.23000213.
Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted. The triglyceride-glucose index (TGI) is found to detect insulin resistance and correlates with DN. The aim of this study is to see the association of TGI and HGI with diabetic nephropathy in type 2 diabetes patients.
234 patients with type 2 diabetes were analyzed retrospectively.
87 (37.2%) of 234 patients were male, and the mean age was 57.2 ± 11.1 years. 76 of the patients had DN. HGI and TGI were significantly higher in the DN group (2.59 ± 1.7 vs. 1.18 ± 0.34; p = 0.00 and 9.9 ± 0.7 vs. 9.7 ± 0.7; p = 0.024). In logistic regression analysis, microalbuminuria was associated with TGI (OR = 3.35, 95% CI, 1.778- 6.32, p = 0.01) and HGI (OR = 2.579, 95% CI, 1.89-3.516, p = 0.00).
In conclusion, TGI and HGI were independently associated with diabetic nephropathy. These markers may be useful in DN, especially in anemic individuals, since anemia might affect HbA1c levels.
糖尿病肾病（DN）是糖尿病的一种严重并发症。尽管空腹血糖（FPG）得到了严格控制，但DN仍可能进展为终末期肾病。糖化血红蛋白（HbA1c）是血糖管理的最佳生物标志物，在FPG相似的情况下可能有所不同。血红蛋白糖化指数（HGI）=测定的HbA1c减去预测的HbA1c。甘油三酯-葡萄糖指数（TGI）被发现可检测胰岛素抵抗并与DN相关。本研究的目的是观察TGI和HGI与2型糖尿病患者糖尿病肾病的关联。
回顾性分析234例2型糖尿病患者。
234例患者中87例（37.2%）为男性，平均年龄为57.2±11.1岁。76例患者患有DN。DN组的HGI和TGI显著更高（2.59±1.7 vs. 1.18±0.34；p = 0.00以及9.9±0.7 vs. 9.7±0.7；p = 0.024）。在逻辑回归分析中，微量白蛋白尿与TGI（OR = 3.35，95%CI，1.778 - 6.32，p = 0.01）和HGI（OR = 2.579，95%CI，1.89 - 3.516，p = 0.00）相关。
总之，TGI和HGI与糖尿病肾病独立相关。这些标志物可能对DN有用，尤其是在贫血个体中，因为贫血可能影响HbA1c水平。
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