Chu Yafen, Yao Hongping, Lu Ni, Chang Yu, Wang Jumei, Xu Linlin, Song Bing, Feng Songtao, Zhang Hui
Department of Endocrinology, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Front Nutr. 2025 Jul 16;12:1628867. doi: 10.3389/fnut.2025.1628867. eCollection 2025.
The triglyceride glucose-body mass index (TyG-BMI) is correlated not only to the onset of diabetic kidney disease (DKD) associated with nutrition (including glucose and triglyceride) metabolism but also incorporates body mass index (BMI), potentially serving as an indicator of non-alcoholic fatty liver disease (NAFLD). But, the links between TyG-BMI and DKD in individuals with and without NAFLD remains further exploration. Therefore, this present research aims to investigate the relationship between TyG-BMI and DKD in these patient groups and to evaluate its diagnostic value for DKD.
A total of 425 individuals diagnosed with type 2 diabetes mellitus (T2DM) were categorized into the DKD group or the Control group. Clinical indicators were compared in these two groups, and the relationships between TyG-BMI and either the estimated glomerular filtration rate (eGFR) or the urinary albumin-to-creatinine ratio (UACR) were examined. Risk factors for DKD were examined, and the diagnostic value of TyG-BMI was assessed in patients without and with NAFLD.
Compared to 288 participants without DKD, 137 individuals with DKD exhibited higher TyG-BMI levels. In all individuals with T2DM, a higher TyG-BMI was recognized as a contributing factor to the development of DKD. Notably, this association was observed in patients without NAFLD, while no such link was established in those diagnosed with NAFLD. For T2DM patients lacking NAFLD, the TyG-BMI threshold of 49.2415 demonstrated a sensitivity of 91.3% and a specificity of 70.1%.
Increased TyG-BMI values are associated with a higher risk of DKD and could act as potential indicators of DKD in individuals with T2DM.
甘油三酯葡萄糖-体重指数（TyG-BMI）不仅与营养（包括葡萄糖和甘油三酯）代谢相关的糖尿病肾病（DKD）发病有关，还纳入了体重指数（BMI），可能作为非酒精性脂肪性肝病（NAFLD）的一个指标。但是，TyG-BMI与有无NAFLD个体的DKD之间的联系仍有待进一步探索。因此，本研究旨在调查这些患者群体中TyG-BMI与DKD之间的关系，并评估其对DKD的诊断价值。
总共425名被诊断为2型糖尿病（T2DM）的个体被分为DKD组或对照组。比较这两组的临床指标，并检查TyG-BMI与估算肾小球滤过率（eGFR）或尿白蛋白与肌酐比值（UACR）之间的关系。检查DKD的危险因素，并评估TyG-BMI在无NAFLD和有NAFLD患者中的诊断价值。
与288名无DKD的参与者相比，137名患有DKD的个体表现出更高的TyG-BMI水平。在所有T2DM个体中，较高的TyG-BMI被认为是DKD发生的一个促成因素。值得注意的是，这种关联在无NAFLD的患者中观察到，但在被诊断为NAFLD的患者中未建立这种联系。对于缺乏NAFLD的T2DM患者，TyG-BMI阈值49.2415的敏感性为91.3%，特异性为70.1%。
TyG-BMI值升高与DKD风险较高相关，并且可以作为T2DM个体中DKD的潜在指标。
