Ahn Bin, Yun Ki Wook, Lee Hoan Jong, Kim Sun Jung, Lee Seong Yeon, Choi Eun Hwa
Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
Arch Virol. 2025 Apr 16;170(5):105. doi: 10.1007/s00705-025-06279-5.
Human adenovirus (HAdV) is a leading cause of respiratory infections, with clinical manifestations and disease severity varying by type. In this study, we analyzed HAdV types in South Korea over a 12-year period before the COVID-19 pandemic. From January 2008 to December 2019, HAdV isolates were prospectively collected from children with suspected respiratory infections at a single tertiary center. HAdV typing was performed through sequence analysis of hexon gene hypervariable regions (HVRs) 1-6. Among 350 HAdV isolates, members of four species (A, B, C, and E) and 10 types (1-6, 31, 34, 35, and 55) were identified. Overall, HAdV-3 was most prevalent (49.4%), followed by HAdV-2 (19.1%), HAdV-1 (14.6%), and HAdV-4 (6.6%). HAdV-3 caused four recurrent outbreaks at intervals of 3 to 4 years without significant genetic changes in the hexon HVRs. HAdV species C (types 1, 2, 5, and 6) was detected endemically throughout the study period. Notably, HAdV-55, which was associated with fatal cases in military recruits in South Korea during 2017-2018, appeared in pediatric cases. HAdV epidemiology studies are important for providing clinical data on circulating HAdVs in children, and there is a need for ongoing surveillance and research.
人腺病毒（HAdV）是呼吸道感染的主要病因，其临床表现和疾病严重程度因类型而异。在本研究中，我们分析了韩国在新冠疫情大流行前12年期间的人腺病毒类型。从2008年1月至2019年12月，前瞻性地从一家三级医疗中心疑似呼吸道感染的儿童中收集人腺病毒分离株。通过对六邻体基因高变区（HVRs）1-6进行序列分析来进行人腺病毒分型。在350株人腺病毒分离株中，鉴定出了四个种（A、B、C和E）的成员以及10种类型（1-6、31、34、35和55）。总体而言，人腺病毒3型最为常见（49.4%），其次是人腺病毒2型（19.1%）、人腺病毒1型（14.6%）和人腺病毒4型（6.6%）。人腺病毒3型每隔3至4年引发4次反复暴发，六邻体HVRs未发生明显基因变化。在整个研究期间均有地方性流行的人腺病毒C种（1、2、5和6型）被检测到。值得注意的是，在2017-2018年期间与韩国新兵死亡病例相关的人腺病毒55型出现在儿科病例中。人腺病毒流行病学研究对于提供儿童中流行的人腺病毒的临床数据很重要，并且有必要持续进行监测和研究。
