Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Clin Infect Dis. 2021 Aug 16;73(4):740-746. doi: 10.1093/cid/ciab146.
Human adenovirus type 4 (HAdV-E4) frequently causes epidemics among military and civilian populations. We conducted a systematic review of 144 peer-reviewed articles reporting HAdV-E4 infections, published during the years 1960-2020. More than 24 500 HAdV-E4 infections, including 27 associated deaths, were documented. HAdV-E4 infections were reported from all geographic regions of the world except Central America and the Caribbean. The number of publications reporting civilian infections tripled in the last decade, with a steady increase in reported civilian infections over time. Infections commonly caused respiratory and ocular disease. North America reported the most infections, followed by Asia and Europe. The majority of deaths were reported in the United States, followed by China and Singapore. Civilians seem to increasingly suffer HAdV-E4 disease, with recent epidemics among US college students. Public health officials should consider seeking emergency use authorization for the adenovirus vaccine such that it might be available to mitigate civilian epidemics.
人腺病毒 4 型（HAdV-E4）经常在军队和平民中引起流行。我们对 1960 年至 2020 年期间发表的 144 篇同行评议的 HAdV-E4 感染报告进行了系统综述。记录了超过 24500 例 HAdV-E4 感染，包括 27 例相关死亡。除中美洲和加勒比地区外，世界各地都有 HAdV-E4 感染的报道。在过去十年中，报告平民感染的出版物数量增加了两倍，报告的平民感染数量随着时间的推移而稳步增加。感染通常导致呼吸道和眼部疾病。北美报告的感染最多，其次是亚洲和欧洲。大多数死亡发生在美国，其次是中国和新加坡。平民似乎越来越多地遭受 HAdV-E4 疾病的困扰，最近美国大学生中爆发了疫情。公共卫生官员应该考虑寻求腺病毒疫苗的紧急使用授权，以便能够减轻平民的疫情。
