Mukada T, Andoh N, Matsushiro T
Tohoku J Exp Med. 1985 Apr;145(4):387-94. doi: 10.1620/tjem.145.387.
To elucidate the morphological characteristics and the incidence of precancerous lesions of the gallbladder, 200 gallbladders removed for presumed benign diseases were examined histopathologically. Dysplastic epithelia with distinct cellular and structural atypia were graded into either mild or moderate to severe degree. Twenty-nine (14.5%) of 200 cases showed dysplasia; 5 (2.5%) was to moderate to severe degree and 24 (12%) to mild degree. Carcinoma in situ was found in 4 cases (2%) and occult invasive carcinoma in 2 cases (1%). Simple hyperplasia was seen in 54 cases (27%). Abnormal epithelia showed a male preponderance in consistent with the previous report on cancer epidemiology in Japan. Dysplasia and hyperplasia were found to have close association with chronic cholecystitis, but not with gallstones per se. It was postulated that the progression of dysplasia or carcinoma in situ into invasive carcinoma may occur in the sixties to seventies.
为阐明胆囊的形态学特征及癌前病变的发生率，对200例因推测为良性疾病而切除的胆囊进行了组织病理学检查。具有明显细胞和结构异型性的发育异常上皮被分为轻度或中度至重度。200例中有29例（14.5%）显示发育异常；5例（2.5%）为中度至重度，24例（12%）为轻度。原位癌4例（2%），隐匿性浸润癌2例（1%）。单纯增生54例（27%）。异常上皮显示男性居多，这与日本先前的癌症流行病学报告一致。发现发育异常和增生与慢性胆囊炎密切相关，但与胆结石本身无关。据推测，发育异常或原位癌向浸润癌的进展可能发生在60至70岁。
