Liu Xiaona, Zheng Juanjuan, Huo Zihan, Wu Feng
Clinical Laboratory, Jinan Mingshui Eye Hospital, Longquan Road, Zhangqiu District, Jinan, 5601, China.
BMC Infect Dis. 2025 Apr 16;25(1):540. doi: 10.1186/s12879-025-10903-9.
There have been no reported cases of infectious diseases associated with Clonostachys rosea.
The patient, 53 years old, was admitted with complaints of "foreign body sensation, tearing, and pain in the left eye for 2 weeks, aggravated for 7 days". And was admitted with a diagnosis of "fungal keratitis (left)". Fungal growth was confirmed through corneal scrape culture. Antifungal treatment included natamycin and fluconazole eye drops, along with oral terbinafine tablets. Levofloxacin eye drops were administered to prevent bacterial infection, and praprofen eye drops were prescribed to alleviate anterior chamber reaction. After 4 days of treatment, the patient reported reduced foreign body sensation, tearing, and pain in the left eye. Follow-up visits were scheduled at regular intervals, during which medication remained consistent and dosage gradually decreased with symptom improvement. After 35 days, ulcer lesions had formed scars, and confocal examination of the corneal focal area revealed normal epithelial cell growth with scar-like reflection below, without obvious mycelial hyperrefraction.
Herein, we describe a case of corneal infection attributed to Clonostachys rosea. We outline the development and treatment of this infection to enhance clinical comprehension and management of similar cases.
此前尚无与粉红粘帚霉相关的传染病病例报道。
患者为一名53岁女性，因“左眼异物感、流泪、疼痛2周，加重7天”入院，诊断为“（左眼）真菌性角膜炎”。通过角膜刮片培养确诊有真菌生长。抗真菌治疗包括那他霉素和氟康唑滴眼液，以及口服特比萘芬片。使用左氧氟沙星滴眼液预防细菌感染，普拉洛芬滴眼液用于减轻前房反应。治疗4天后，患者左眼异物感、流泪和疼痛减轻。定期安排随访，在此期间用药保持一致，且随着症状改善剂量逐渐减少。35天后，溃疡病变形成瘢痕，角膜病灶区域共焦检查显示上皮细胞生长正常，下方有瘢痕样反光，无明显菌丝高反光。
在此，我们描述了一例由粉红粘帚霉引起的角膜感染病例。我们概述了该感染的发展及治疗过程，以提高对类似病例的临床认识和管理水平。
