Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
Mycoses. 2020 Nov;63(11):1203-1214. doi: 10.1111/myc.13169. Epub 2020 Sep 9.
The genera Acremonium and Sarocladium comprise a high diversity of morphologically and genetically related fungi generally found in the environment, although a few species, mainly Sarocladium kiliense and Acremonium egyptiacum, can also be involved in many human infections. Clinical management of opportunistic infections caused by these fungi is very complex, since their correct identification is unreliable, and they generally show poor antifungal response. More than 300 clinical cases involving a broad range of Acremonium/Sarocladium infections have so far been published, and with this review we aim to compile and provide a detailed overview of the current knowledge on Acremonium/Sarocladium human infections in terms of presentation, diagnosis, treatments and prognoses. We also aim to summarise and discuss the data currently available on their antifungal susceptibility, emphasising the promising results obtained with voriconazole as well as their impact in terms of animal infections.
阿克曼菌属和萨拉氏菌属包含了高度多样化的形态学和遗传学相关真菌，这些真菌通常存在于环境中，尽管少数几种，主要是萨拉氏菌属和阿克曼菌属埃及变种，也可能涉及多种人类感染。这些真菌引起的机会性感染的临床管理非常复杂，因为它们的正确鉴定不可靠，而且它们通常对抗真菌药物的反应较差。迄今为止，已经发表了超过 300 例涉及广泛阿克曼菌属/萨拉氏菌属感染的临床病例，通过本次综述，我们旨在汇编并提供阿克曼菌属/萨拉氏菌属人类感染在临床表现、诊断、治疗和预后方面的最新知识概述。我们还旨在总结和讨论目前关于它们抗真菌药物敏感性的数据，强调伏立康唑的有前途的结果，以及它们在动物感染方面的影响。
