Ikawa M, Carr C, Tatsuno T
Toxicon. 1985;23(3):535-7. doi: 10.1016/0041-0101(85)90040-6.
Using the paper-disk method with Chlorella-seeded agar plates, 15-acetoxyscirpenol, HT-2 toxin, acetyl T-2 toxin and neosolaniol inhibited growth at a concentration of 1 mg/ml, whereas verrucarol, T-2 tetraol, nivalenol, fusarenon-X, deoxynivalenol and 3-acetyldeoxynivalenol were inactive. Taking into account that verrucarin A, roridin A, T-2 toxin and diacetoxyscirpenol had previously been found to strongly inhibit Chlorella growth, esterification at R15 appears to be important for growth inhibitory activity. The most active agents are also esterified at R4. Inhibition of protein synthesis appears to be involved in the toxicity.
采用纸碟法，在接种小球藻的琼脂平板上，15 - 乙酰氧基镰刀菌烯醇、HT - 2毒素、乙酰T - 2毒素和新茄病镰刀菌烯醇在浓度为1毫克/毫升时抑制生长，而疣孢菌素A、T - 2四醇、雪腐镰刀菌烯醇、镰刀菌烯酮 - X、脱氧雪腐镰刀菌烯醇和3 - 乙酰脱氧雪腐镰刀菌烯醇则无活性。鉴于之前已发现疣孢菌素A、瑞替菌素A、T - 2毒素和二乙酰氧基镰刀菌烯醇能强烈抑制小球藻生长，R15位的酯化似乎对生长抑制活性很重要。活性最强的药剂在R4位也被酯化。蛋白质合成的抑制似乎与毒性有关。
