Yagen B, Halevy S
Experientia. 1987 Aug 15;43(8):886-8. doi: 10.1007/BF01951651.
Several trichothecene mycotoxins were shown to inhibit the growth of Saccharomyces cerevisiae. This effect was most pronounced with the macrocyclic trichothecenes, especially verrucarin A. Much less growth inhibition was observed with T-2 toxin. Verrucarol, diacetoxyscirpenol, acetyl T-2 toxin, HT-2 toxin, T-2 tetraol and neosolaniol were inactive at a concentration of 75 micrograms of toxin per disc. Incubation of S. cerevisiae with verrucarin A together with vitamins resulted in a decrease in toxicity. Pyridoxine-HCl, Ca-pantothenate, thiamine-HCl and alpha-tocopheryl acetate were amongst the most potent of the vitamins tested which reversed growth inhibition, overcoming the inhibitory potential of the toxins.
几种单端孢霉烯族霉菌毒素被证明可抑制酿酒酵母的生长。这种作用在大环单端孢霉烯族毒素中最为明显，尤其是疣孢菌素A。观察到T-2毒素对生长的抑制作用要小得多。疣孢醇、二醋酸藨草镰刀菌烯醇、乙酰T-2毒素、HT-2毒素、T-2四醇和新茄病镰刀菌烯醇在每片含75微克毒素的浓度下无活性。将酿酒酵母与疣孢菌素A以及维生素一起培养会导致毒性降低。盐酸吡哆醇、泛酸钙、盐酸硫胺素和醋酸生育酚是所测试的最有效的维生素，它们可逆转生长抑制，克服毒素的抑制潜力。
