Akkaya Serkan, Güvenç Umay, Balıkçı Ayşe, Demirok Gülizar, Özkan Güner, Uzman Selma, Ertürk Naci, Burcu Ayşe
Department of Ophthalmology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
Eur J Ophthalmol. 2025 Sep;35(5):1637-1646. doi: 10.1177/11206721251334163. Epub 2025 Apr 17.
PurposeTo compare the thicknesses of each retinal layer in patients with clinically unilateral pseudoexfoliation syndrome (XFS) versus unaffected fellow eyes and healthy age-matched controls.MethodsIn this cross-sectional study, a complete ophthalmologic evaluation, including intraocular pressure (IOP) measurement, was performed in 40 patients with unilateral XFS-affected and 43 healthy controls. After confirming that fellow eyes were clinically unaffected, all eyes underwent the retinal layer segmentation analysis using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). The thickness maps were divided into nine subfields (i.e., 1-mm, 3-mm, and 6-mm grids) using the Early Treatment Diabetic Retinopathy Study (ETDRS) and were extracted from the software to compare the groups.ResultsIn the 1-mm central subfield, thicknesses of the ganglion cell layer (GCL), inner plexiform layer (IPL), and inner retinal layer (IRL) were significantly reduced both in XFS-affected and fellow eyes than in controls. Additionally, the thicknesses of the inner nuclear layer (INL) and outer plexiform layer (OPL) were significantly reduced in fellow eyes compared to controls. Comparison of XFS-affected versus fellow eyes in the 1-mm central subfield showed no significant differences in GCL, IPL, IRL, INL, and OPL thicknesses (> 0.05, for all; Tukey HSD test). In ETDRS subfields, 3-mm temporal and 3-mm inferior IPL thicknesses of fellow eyes and 6-mm temporal INL thickness in XFS-affected eyes were reduced compared to controls (< 0.05, for all).ConclusionIn clinically unilateral XFS, the consequential thinning of retinal layers in the fellow eye accompanies the significant thinning of retinal layers in the affected eye.
目的
比较临床单侧假性剥脱综合征（XFS）患者患眼与未受影响的对侧眼以及年龄匹配的健康对照者各视网膜层的厚度。
方法
在这项横断面研究中，对40例单侧XFS患者和43名健康对照者进行了包括眼压（IOP）测量在内的全面眼科评估。在确认对侧眼临床未受影响后，所有眼睛均使用增强深度成像光谱域光学相干断层扫描（EDI SD-OCT）进行视网膜层分割分析。使用糖尿病视网膜病变早期治疗研究（ETDRS）将厚度图分为九个子区域（即1毫米、3毫米和6毫米网格），并从软件中提取以比较各组。
结果
在1毫米中央子区域，XFS患眼和对侧眼的神经节细胞层（GCL）、内网状层（IPL）和视网膜内层（IRL）厚度均显著低于对照组。此外，与对照组相比，对侧眼的内核层（INL）和外网状层（OPL）厚度显著降低。在1毫米中央子区域中，XFS患眼与对侧眼的GCL、IPL、IRL、INL和OPL厚度比较无显著差异（所有P>0.05；Tukey HSD检验）。在ETDRS子区域中，与对照组相比，对侧眼的3毫米颞侧和3毫米下方IPL厚度以及XFS患眼的6毫米颞侧INL厚度降低（所有P<0.05）。
结论
在临床单侧XFS中，对侧眼视网膜层的相应变薄与患眼视网膜层的显著变薄同时出现。
