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开发并分析用于槌状趾植入物的纳米复合材料涂层材料。

Developing and analyzing a Nanocomposites coated material for hammertoe implants.

作者信息

Ramesh Gayathri, Dommeti Vamsi Krishna, Kumar Hari Raj, Sadasivam Gnanavel

机构信息

Biomaterials Laboratory, Department of Biomedical Engineering, SRM Institute of Science and Technology, Kattankulathur Campus, Chengalpattu, TamilNadu - 603 203, India.

Department of Mechanical Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur Campus, Chengalpattu, TamilNadu - 603 203, India.

出版信息

J Orthop. 2025 Jan 19;62:182-190. doi: 10.1016/j.jor.2025.01.016. eCollection 2025 Apr.

Abstract

Hammertoe implants, frequently used for arthroplasty or proximal interphalangeal joint arthrodesis, have serious drawbacks because of bacterial colonization and material corrosion, which can result in infections and other problems. This study creates a new nanocomposite covering to improve the corrosion resistance, antibacterial qualities, and biocompatibility of 316L stainless steel (SS). 316L SS was treated with a nanocomposite made of graphene oxide (GO), zirconia (ZrO₂), and hydroxyapatite (HAp). The coating's structural and functional characteristics were examined using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). Standard assays were used to evaluate the coated material's antibacterial activity, and simulated bodily fluid (SBF) was used to assess corrosion resistance in vitro. Biocompatibility was verified using assays for cell survival. Apatite layer formation during SBF immersion indicated increased bioactivity and the results showed that the HAp-ZrO₂-GO nanocomposite coating greatly increased the corrosion resistance of 316L SS. The coating showed anti-inflammatory and potent antibacterial qualities, successfully preventing bacterial colonization. Additionally, cell survival tests verified the coated material's biocompatibility, indicating that it would be safe for use in biomedical applications. This work presents a scalable and reasonably priced process for creating bioactive nanocomposite coatings for medical implants. The HAp-ZrO₂-GO coating addresses important drawbacks of conventional implant materials by improving physico-chemical interactions and providing better performance. With significant ramifications for developing biomedical engineering and enhancing patient outcomes, these results demonstrate the potential of the HAp-ZrO₂-GO nanocomposite as a workable option for long-lasting, antimicrobial, and biocompatible bioimplant coatings.

摘要

锤状趾植入物常用于关节成形术或近端指间关节融合术,但由于细菌定植和材料腐蚀会导致感染及其他问题,存在严重缺陷。本研究制备了一种新型纳米复合材料涂层,以提高316L不锈钢(SS)的耐腐蚀性、抗菌性能和生物相容性。用氧化石墨烯(GO)、氧化锆(ZrO₂)和羟基磷灰石(HAp)制成的纳米复合材料对316L SS进行处理。采用傅里叶变换红外光谱(FTIR)、扫描电子显微镜(SEM)和能量色散X射线光谱(EDX)对涂层的结构和功能特性进行检测。使用标准试验评估涂层材料的抗菌活性,并用模拟体液(SBF)评估体外耐腐蚀性。通过细胞存活试验验证生物相容性。SBF浸泡过程中磷灰石层的形成表明生物活性增强,结果表明HAp-ZrO₂-GO纳米复合涂层大大提高了316L SS的耐腐蚀性。该涂层具有抗炎和强效抗菌性能,成功防止了细菌定植。此外,细胞存活试验验证了涂层材料的生物相容性,表明其用于生物医学应用是安全的。这项工作提出了一种可扩展且价格合理的方法来制备用于医疗植入物的生物活性纳米复合涂层。HAp-ZrO₂-GO涂层通过改善物理化学相互作用并提供更好的性能,解决了传统植入材料的重要缺陷。这些结果表明HAp-ZrO₂-GO纳米复合材料作为持久、抗菌和生物相容的生物植入涂层的可行选择具有潜力,对生物医学工程的发展和改善患者预后具有重要意义。

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