针对淋球菌感染的类别特异性抗体反应。
Class specific antibody response to gonococcal infection.
作者信息
Miettinen A, Hakkarainen K, Grönroos P, Heinonen P, Teisala K, Aine R, Sillantaka I, Saarenmaa K, Lehtinen M, Punnonen R
机构信息
Department of Biomedical Sciences, University of Tampere, Finland.
出版信息
J Clin Pathol. 1989 Jan;42(1):72-6. doi: 10.1136/jcp.42.1.72.
An enzyme immunoassay was used to determine IgM, IgG, and IgA antibodies to gonococcal pili in 68 patients with uncomplicated gonorrhoea, 35 women with pelvic inflammatory disease, and in 115 normal controls. A clear difference in response rate in all three antibody classes between patients with gonorrhoea and healthy controls was evident. Among women with gonorrhoea, the magnitude of antibody response was higher than among men with gonorrhoea, especially in the IgM class. No major differences were found in the overall distribution of serological findings between women with uncomplicated gonorrhoea and those with gonococcal pelvic inflammatory disease. Among this last group, however, high IgM antibody levels in acute phase sera were significantly associated with the isolation of Neisseria gonorrhoeae in the upper genital tract.
采用酶免疫分析法检测了68例单纯性淋病患者、35例盆腔炎女性患者及115名正常对照者血清中抗淋球菌菌毛的IgM、IgG和IgA抗体。淋病患者与健康对照者在所有三种抗体类型的反应率上存在明显差异。在淋病女性患者中，抗体反应强度高于淋病男性患者，尤其是IgM类。单纯性淋病女性患者与淋菌性盆腔炎女性患者的血清学检查结果总体分布无显著差异。然而，在最后一组患者中，急性期血清中高IgM抗体水平与上生殖道淋病奈瑟菌的分离显著相关。
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