卡介苗接种对小鼠非结核分枝杆菌感染的预防作用。

Prophylactic effect in mice of BCG vaccination against nontuberculous mycobacterial infections.

作者信息

Orme I M, Collins F M

出版信息

Tubercle. 1985 Jun;66(2):117-20. doi: 10.1016/0041-3879(85)90076-5.

Abstract

The effect of prior vaccination of mice with Mycobacterium bovis BCG on the subsequent course of acute aerogenic infection with various environmental mycobacteria was tested. A protective effect was recorded against infection with M. avium, and M. kansasii; by contrast no effect was noted against M. simiae or M. intracellulare. The prophylactic effects of BCG were demonstrated regardless of whether vaccination was given by the intravenous or aerogenic routes. These findings support the hypothesis that BCG vaccination, if given prior to contact, can provide some degree of protection against certain non-tuberculous mycobacterial infections.

摘要

对小鼠预先接种牛分枝杆菌卡介苗（Mycobacterium bovis BCG），然后观察其随后感染各种环境分枝杆菌的急性空气传播感染病程，进行了相关测试。结果发现，接种牛分枝杆菌卡介苗对鸟分枝杆菌（M. avium）和堪萨斯分枝杆菌（M. kansasii）的感染具有保护作用；相比之下，对猿分枝杆菌（M. simiae）或胞内分枝杆菌（M. intracellulare）则没有保护作用。无论通过静脉注射还是空气传播途径进行接种，均证实了卡介苗的预防效果。这些研究结果支持了这样一种假设，即如果在接触之前接种卡介苗，可以提供一定程度的保护，预防某些非结核分枝杆菌感染。