Li Niying, Borate Samruddhi Nandkumar, Zhang Kai, Zuber Mohammed, Han Yiran, Chudasama Darshan, Correia Stephen, Renzi-Hammond Lisa
Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, Georgia, USA.
Department of Population and Community Health, College of Public Health, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA.
Alzheimers Dement. 2025 Apr;21(4):e70100. doi: 10.1002/alz.70100.
The approval of lecanemab-irmb offers potential disease-modifying treatments for Alzheimer's disease (AD), but geographical access barriers to infusion and amyloid positron emission tomography (PET) imaging sites might prevent timely access to the drug. We examined disparities in access to lecanemab infusion sites and amyloid PET scan facilities in Georgia's 159 counties.
Facility location maps were used to examine lecanemab access. We used drive time analysis to identify and map counties by drive time.
No rural county had an amyloid PET scan center and only one had a lecanemab infusion center. Residents in rural counties need to drive > 1 hour on average to reach the nearest facility, which is statistically significantly longer than those in non-rural counties.
Lack of access and long drive times pose health equity issues for those in rural counties, which already have a higher percentage of older residents and a higher prevalence of behavioral AD risk factors.
We mapped amyloid positron emission tomography (PET) scan and lecanemab infusion facilities in Georgia. We examined the drive time to the nearest facility in each county. One lecanemab infusion facility and no amyloid PET scan facilities were found in rural counties. The mean drive time to the nearest facility is significantly longer for rural counties. The results call for policies and resources to address this health disparity issue.
lecanemab-irmb的获批为阿尔茨海默病(AD)提供了潜在的疾病修饰治疗方法,但输液和淀粉样蛋白正电子发射断层扫描(PET)成像地点的地理获取障碍可能会妨碍及时获得该药物。我们研究了佐治亚州159个县在获取lecanemab输液地点和淀粉样蛋白PET扫描设施方面的差异。
使用设施位置地图来研究lecanemab的获取情况。我们通过驾车时间分析来识别各县并绘制驾车时间地图。
没有一个农村县有淀粉样蛋白PET扫描中心,只有一个县有lecanemab输液中心。农村县的居民平均需要驾车1小时以上才能到达最近的设施,这在统计学上显著长于非农村县的居民。
获取困难和驾车时间长给农村县的居民带来了健康公平问题,而农村县老年居民的比例已经较高,行为性AD风险因素的患病率也较高。
我们绘制了佐治亚州淀粉样蛋白正电子发射断层扫描(PET)扫描和lecanemab输液设施的地图。我们研究了各县到最近设施的驾车时间。农村县发现了一个lecanemab输液设施,没有淀粉样蛋白PET扫描设施。农村县到最近设施的平均驾车时间明显更长。研究结果呼吁制定政策并提供资源来解决这一健康差异问题。