儿童肺炎中局部与全身细胞因子动力学

Local Versus Systemic Cytokine Dynamics in Pediatric Pneumonia.

作者信息

Lin Jilei, Tang Mingyu, Yuan Shuhua, Chen Jiande, Yang Guijun, Zhang Huishan, Li Wanlin, Zhang Jing, Zhang Lei, Yin Yong

机构信息

Department of Respiratory Medicine, Shanghai Jiaotong University School of Medicine, Shanghai Children's Medical Center, Shanghai, China.

International Medical Department, Shanghai Jiaotong University School of Medicine, Shanghai Children's Medical Center, Shanghai, China.

出版信息

Pediatr Pulmonol. 2025 Apr;60(4):e71093. doi: 10.1002/ppul.71093.

DOI:10.1002/ppul.71093

PMID:40243399

Abstract

No significant correlation was observed between most local and systemic cytokines in children with pneumonia. The observed elevation of specific cytokines such as IL-2, IL-2R, and IL-4 in the BALF of pneumonia patients, alongside increases in IL-2, IL-6, and IL-12p70 in peripheral blood, underscores the robust local and systemic inflammatory response in pneumonia.

摘要

在肺炎患儿中，大多数局部和全身细胞因子之间未观察到显著相关性。肺炎患者支气管肺泡灌洗液（BALF）中白细胞介素-2（IL-2）、白细胞介素-2受体（IL-2R）和白细胞介素-4等特定细胞因子升高，同时外周血中IL-2、IL-6和IL-12p70增加，这突出了肺炎中强烈的局部和全身炎症反应。