Pérol Olivia, Remion Rejane, Charbotel Barbara, Fervers Béatrice
Département Prévention Cancer Environnement, Centre Léon Bérard, Lyon, France / INSERM U1296 Radiations : Défense, Santé, Environnement, Centre Léon Bérard, Lyon, France.
UMRESTTE (Unité Mixte IFSTTAR/UCBL), Université Lyon 1, Lyon, France / Service des Maladies Professionnelles, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
Med Lav. 2025 Apr 17;116(2):16270. doi: 10.23749/mdl.v116i2.16270.
Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hospitals in the Rhône-Alpes region.
Patients received a self-administered questionnaire to fill in at home to collect their job history and potential occupational exposures to carcinogens. A physician assessed the questionnaire to determine if a dedicated consultation was required and the possibility of claiming compensation. Patients were systematically assisted by a social worker for administrative procedures.
In 12 months, 754 patients were enrolled in the study, and 361 (48%) returned the questionnaire. A specialized consultation was proposed for 123 patients, and 98 patients attended the consultation. Overall, a compensation claim was proposed to 18 patients: 11 have been occupationally exposed to pesticides and seven to trichloroethylene.
Our results confirmed the feasibility of the systematic screening procedure. Barriers were observed at every step of the process, and it underlined that patients are rarely nformed about occupational exposures. As the prevalence of occupational exposures in malignant hemopathies remains scarce, a systematic targeted screening could be relevant in this population.
多项研究强调了环境暴露在恶性血液病病因学中的作用。一些恶性血液病患者可被认定为职业病并获得赔偿。前淋巴细胞白血病研究旨在对罗讷-阿尔卑斯地区三家医院治疗的淋巴瘤或骨髓瘤患者的职业暴露进行系统筛查。
患者在家中自行填写问卷，以收集其工作经历和潜在的致癌物职业暴露情况。医生对问卷进行评估，以确定是否需要进行专门会诊以及申请赔偿的可能性。患者在行政程序方面会得到一名社会工作者的系统协助。
在12个月内，754名患者纳入研究，361名（48%）患者返回了问卷。为123名患者提供了专门会诊，98名患者参加了会诊。总体而言，向18名患者提出了赔偿申请：11名患者有农药职业暴露史，7名有三氯乙烯职业暴露史。
我们的结果证实了系统筛查程序的可行性。在该过程的每个步骤都发现了障碍，并且突出表明患者很少了解职业暴露情况。由于恶性血液病中职业暴露的患病率仍然很低，因此对该人群进行系统的针对性筛查可能是有意义的。
