Marotto Luiza Schettini, Marotto Marcia Schettini, Barrese Tomás Zecchini, Borges Cinthya Dos Santos Cirqueira, Guerra Juliana Mariotti, Araújo Leonardo José Tadeu de, Ferreira Camila Santos da Silva, Nassar Filho Amir, Marotto Paulo Cesar Fumagalli
Hospital Municipal Antonio Giglio, Osasco, São Paulo, Brazil.
Instituto Adolfo Lutz, Departamento de Patologia, São Paulo, São Paulo, Brazil.
Rev Inst Med Trop Sao Paulo. 2025 Apr 14;67:e26. doi: 10.1590/S1678-9946202567026. eCollection 2025.
Coinfection with leptospirosis and other infectious agents pose major challenges in medical practice, often due to difficulties in isolating these agents, symptoms overlap, and lack of specific investigation protocols in areas with emerging and re-emerging diseases. Consequently, knowledge regarding these coinfections and their impact on clinical outcomes are limited. A previously healthy 33-year-old woman, with no history of chronic or malignance diseases, was admitted with febrile icteric illness, pulmonary hemorrhage, acute kidney injury, thrombocytopenia, and shock. Leptospirosis, COVID-19, human rhinovirus, and dengue in the acute phase were clinically and pathologically diagnosed. Multiple coinfections can rapidly lead to multiple organ and system failure, often resulting in a fatal outcome.
钩端螺旋体病与其他感染原的合并感染给医疗实践带来了重大挑战，这通常是由于分离这些病原体存在困难、症状重叠，以及在新出现和再次出现疾病的地区缺乏特定的调查方案。因此，关于这些合并感染及其对临床结果影响的知识有限。一名33岁的既往健康女性，无慢性或恶性疾病史，因发热性黄疸疾病、肺出血、急性肾损伤、血小板减少和休克入院。急性期的钩端螺旋体病、新型冠状病毒肺炎、人鼻病毒和登革热经临床和病理诊断。多种合并感染可迅速导致多器官和系统衰竭，常导致致命后果。
