文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

将趋磁细菌工程化为医用微型机器人。

Engineering Magnetotactic Bacteria as Medical Microrobots.

作者信息

Wang Jiaqi, Xing Yi, Ngatio Michael, Bies Paulina, Xu Lu Lucy, Xing Liuxi, Zarea Ahmed, Makela Ashley V, Contag Christopher H, Li Jinxing

机构信息

Department of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.

Program in Cellular and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

出版信息

Adv Mater. 2025 Jul;37(27):e2416966. doi: 10.1002/adma.202416966. Epub 2025 Apr 17.


DOI:10.1002/adma.202416966
PMID:40244080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12243727/
Abstract

Nature's ability to create complex and functionalized organisms has long inspired engineers and scientists to develop increasingly advanced machines. Magnetotactic bacteria (MTB), a group of Gram-negative prokaryotes that biomineralize iron and thrive in aquatic environments, have garnered significant attention from the bioengineering community. These bacteria possess chains of magnetic nanocrystals known as magnetosomes, which allow them to align with Earth's geomagnetic field and navigate through aquatic environments via magnetotaxis, enabling localization to areas rich in nutrients and optimal oxygen concentration. Their built-in magnetic components, along with their intrinsic and/or modified biological functions, make them one of the most promising platforms for future medical microrobots. Leveraging an externally applied magnetic field, the motion of MTBs can be precisely controlled, rendering them suitable for use as a new type of biohybrid microrobotics with great promise in medicine for bioimaging, drug delivery, cancer therapy, antimicrobial treatment, and detoxification. This mini-review provides an up-to-date overview of recent advancements in MTB microrobots, delineates the interaction between MTB microrobots and magnetic fields, elucidates propulsion mechanisms and motion control, and reports state-of-the-art strategies for modifying and functionalizing MTB for medical applications.

摘要

自然界创造复杂且功能化生物体的能力长期以来一直激励着工程师和科学家开发日益先进的机器。趋磁细菌(MTB)是一类革兰氏阴性原核生物,它们能生物矿化铁并在水生环境中繁衍生息,已引起生物工程界的广泛关注。这些细菌拥有被称为磁小体的磁性纳米晶体链,这使它们能够与地球的地磁场对齐,并通过趋磁作用在水生环境中导航,从而定位到富含营养物质和具有最佳氧气浓度的区域。它们内置的磁性组件,以及其固有的和/或经过修饰的生物学功能,使其成为未来医用微型机器人最有前景的平台之一。利用外部施加的磁场,可以精确控制趋磁细菌的运动,使其适合用作一种新型的生物杂交微型机器人,在医学上的生物成像、药物递送、癌症治疗、抗菌治疗和解毒等方面具有巨大潜力。本综述提供了趋磁细菌微型机器人最新进展的概述,阐述了趋磁细菌微型机器人与磁场之间的相互作用,阐明了推进机制和运动控制,并报告了用于医学应用的趋磁细菌修饰和功能化的最新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/65afa34cf17d/ADMA-37-2416966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/1dd8fef52863/ADMA-37-2416966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/c5aa0dec1438/ADMA-37-2416966-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/f8aa0bd52c2c/ADMA-37-2416966-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/a0ac31c69487/ADMA-37-2416966-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/f652baacae7b/ADMA-37-2416966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/10cf2e2cf2ed/ADMA-37-2416966-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/267eaee003a5/ADMA-37-2416966-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/65afa34cf17d/ADMA-37-2416966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/1dd8fef52863/ADMA-37-2416966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/c5aa0dec1438/ADMA-37-2416966-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/f8aa0bd52c2c/ADMA-37-2416966-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/a0ac31c69487/ADMA-37-2416966-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/f652baacae7b/ADMA-37-2416966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/10cf2e2cf2ed/ADMA-37-2416966-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/267eaee003a5/ADMA-37-2416966-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac6/12243727/65afa34cf17d/ADMA-37-2416966-g002.jpg

相似文献

[1]
Engineering Magnetotactic Bacteria as Medical Microrobots.

Adv Mater. 2025-7

[2]
Sexual Harassment and Prevention Training

2025-1

[3]
Short-Term Memory Impairment

2025-1

[4]
Management of urinary stones by experts in stone disease (ESD 2025).

Arch Ital Urol Androl. 2025-6-30

[5]
[Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data].

Epidemiol Prev. 2013

[6]
Survivor, family and professional experiences of psychosocial interventions for sexual abuse and violence: a qualitative evidence synthesis.

Cochrane Database Syst Rev. 2022-10-4

[7]
How lived experiences of illness trajectories, burdens of treatment, and social inequalities shape service user and caregiver participation in health and social care: a theory-informed qualitative evidence synthesis.

Health Soc Care Deliv Res. 2025-6

[8]
The Black Book of Psychotropic Dosing and Monitoring.

Psychopharmacol Bull. 2024-7-8

[9]
Home treatment for mental health problems: a systematic review.

Health Technol Assess. 2001

[10]
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev. 2021-4-19

引用本文的文献

[1]
Updates on the Advantages and Disadvantages of Microscopic and Spectroscopic Characterization of Magnetotactic Bacteria for Biosensor Applications.

Biosensors (Basel). 2025-7-22

[2]
Biomaterials mediated 3R (remove-remodel-repair) strategy: holistic management of Helicobacter pylori infection.

J Nanobiotechnology. 2025-7-1

本文引用的文献

[1]
Advanced materials for micro/nanorobotics.

Chem Soc Rev. 2024-9-16

[2]
Precisely Navigated Biobot Swarms of Bacteria for Water Decontamination.

ACS Appl Mater Interfaces. 2023-2-8

[3]
A review on microrobots driven by optical and magnetic fields.

Lab Chip. 2023-3-1

[4]
Magnetic torque-driven living microrobots for increased tumor infiltration.

Sci Robot. 2022-10-26

[5]
Tumor inhibition via magneto-mechanical oscillation by magnetotactic bacteria under a swing MF.

J Control Release. 2022-11

[6]
Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery.

Sci Adv. 2022-7-15

[7]
Magnetic Particle Imaging of Magnetotactic Bacteria as Living Contrast Agents Is Improved by Altering Magnetosome Arrangement.

Nano Lett. 2022-6-22

[8]
Biomineralization and biotechnological applications of bacterial magnetosomes.

Colloids Surf B Biointerfaces. 2022-8

[9]
Smart Magnetotactic Bacteria Enable the Inhibition of Neuroblastoma under an Alternating Magnetic Field.

ACS Appl Mater Interfaces. 2022-3-30

[10]
Magnetotactic bacteria: concepts, conundrums, and insights from a novel in situ approach using digital holographic microscopy (DHM).

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2022-1

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索