α-肾上腺素能阻滞对猴子脊髓自动调节的影响。

The effect of alpha adrenergic blockade on spinal cord autoregulation in the monkey.

作者信息

Kobrine A I, Evans D E, Rizzoli H V

出版信息

J Neurosurg. 1977 Mar;46(3):336-41. doi: 10.3171/jns.1977.46.3.0336.

DOI:10.3171/jns.1977.46.3.0336

Abstract

Spinal cord blood flow (SCBF) was measured over a wide range of artificially varied mean systemic arterial blood pressures (MAP) in a group of monkeys with alpha adrenergic receptors blocked by the intravenous administration of phenoxybenzamine (Dibenzyline). The SCBF was found to vary linearly with changes in MAP. Autoregulation appeared to have been abolished. These data are cited as evidence for a dominant role of the sympathetic nervous system in control of the spinal circulation.

摘要

在一组通过静脉注射酚苄明（双苄胺）阻断α肾上腺素能受体的猴子中，在广泛的人工改变的平均体动脉血压（MAP）范围内测量脊髓血流量（SCBF）。发现SCBF随MAP的变化呈线性变化。自调节似乎已被消除。这些数据被引为交感神经系统在脊髓循环控制中起主导作用的证据。