Kobrine A I, Doyle T F, Rizzoli H V
J Neurosurg. 1976 Jan;44(1):12-5. doi: 10.3171/jns.1976.44.1.0012.
The authors used the hydrogen clearance method to measure focal spinal cord blood flow (SCBF) in the rhesus monkey over a wide range of mean arterial blood pressures (MAP) in an attempt to test the hypothesis of autoregulation. The MAP was either lowered by bleeding or raised by the intravenous infusion of norepinephrine or angiotensin. The SCBF remained constant and in the normal range with an MAP of 50 to 135 mm Hg, indicating the presence of autoregulation. Below 50 mm Hg, SCBF fell passively with further decreases in MAP. At MAP values above 135 mm Hg, vasodilatation occurred which resulted in a breakthrough of autoregulation and marked increases in SCBF with further increases in the MAP.
作者使用氢清除法在恒河猴身上，于较宽范围的平均动脉血压（MAP）下测量局部脊髓血流（SCBF），以试图检验自动调节假说。MAP通过放血降低，或通过静脉输注去甲肾上腺素或血管紧张素升高。当MAP在50至135 mmHg时，SCBF保持恒定且处于正常范围，表明存在自动调节。低于50 mmHg时，随着MAP进一步降低，SCBF被动下降。在MAP值高于135 mmHg时，发生血管舒张，导致自动调节突破，且随着MAP进一步升高，SCBF显著增加。
