[实验性肉毒中毒时呼吸肌能量代谢受损的机制]
[Mechanism of impairment of energy metabolism in respiratory muscles in experimental botulism].
作者信息
Morrison V V
出版信息
Vopr Med Khim. 1985 May-Jun;31(3):64-7.
PMID:4024533
Abstract
Phase alterations in content of adenylic nucleotides were observed in muscular and nervous tissues in dynamics of botulinic intoxication in rats. Experiments with administration of 4-aminopyridine and alpha-tocopherol showed that a decreased rate of mediator liberation in cholinergic synapses and activation of lipid peroxidation were apparently responsible for impairments in energy metabolism.
摘要
在大鼠肉毒中毒的动态过程中，观察到肌肉和神经组织中腺苷酸含量的相位变化。给予4-氨基吡啶和α-生育酚的实验表明，胆碱能突触中介质释放速率降低和脂质过氧化激活显然是能量代谢受损的原因。
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