Gherasim Alina, Dietsch Frank, Odul Florian, Riff Thibaut, Domis Nathalie, de Blay Frederic
ALYATEC Clinical Research Center, 1 place de l'Hôpital, 67000, Strasbourg, France.
ALYATEC Clinical Research Center, 1 place de l'Hôpital, 67000, Strasbourg, France.
Respir Med. 2025 Jun;242:108105. doi: 10.1016/j.rmed.2025.108105. Epub 2025 Apr 15.
Air cleaners improve indoor air quality by reducing pollutants and airborne allergens. Only a few clinical studies showed their efficacy in respiratory diseases in environmental exposure chambers (EECs).
To assess the efficacy of the Dyson HEPA H13 filter (Big + Quiet Formaldehyde) air cleaner on allergic responses in cat-allergic patients.
This single-center, randomized, double-blind, parallel-group study enrolled 30 GINA 1-2 cat-asthmatic patients with or without allergic rhinoconjunctivitis. Patients were included (Visit 1) according to their allergy and asthma history and skin prick testing for cat allergens. At randomization (Visit 2), patients presented early asthma response (EAR), during 2-h exposures to 80 ng/m of cat allergen in ALYATEC EEC. A second allergen exposure (Visit 3) evaluated the impact of air cleaners on bronchial, nasal and ocular responses as compared to placebo.
EAR was significantly delayed in the active group (p = 0.02). After 50 min of exposure, no patient developed EAR in the active group, compared to 53.3 % in the placebo group. FEV 1 rates were reduced in 40 % of EAR in the active group compared to 73.3 % in the placebo group (p = 0.06). Air cleaners reduced rhino-conjunctivitis by 52.2 % with a mean TSS of 1.6 compared to 3.3 in the placebo group (p = 0.03). Rhinitis responses were improved in the active group, compared to placebo (p = 0.03). Air cleaners decreased cat allergen from 79.6 ng/m to 14.2 ng/m CONCLUSIONS: Air cleaners improved clinical allergic responses during cat allergen exposures in ALYATEC EEC.
空气净化器通过减少污染物和空气传播的过敏原来改善室内空气质量。只有少数临床研究表明其在环境暴露舱（EEC）中对呼吸道疾病的疗效。
评估戴森HEPA H13滤网（大+安静除甲醛）空气净化器对猫过敏患者过敏反应的疗效。
这项单中心、随机、双盲、平行组研究纳入了30名GINA 1-2级的猫哮喘患者，伴有或不伴有过敏性鼻结膜炎。根据患者的过敏和哮喘病史以及对猫过敏原的皮肤点刺试验纳入研究（第1次就诊）。在随机分组时（第2次就诊），患者在ALYATEC EEC中暴露于80 ng/m³的猫过敏原2小时期间出现早期哮喘反应（EAR）。第二次过敏原暴露（第3次就诊）评估了与安慰剂相比空气净化器对支气管、鼻腔和眼部反应的影响。
活性组的EAR明显延迟（p = 0.02）。暴露50分钟后，活性组无患者出现EAR，而安慰剂组为53.3%。活性组40%的EAR患者FEV₁率降低，而安慰剂组为73.3%（p = 0.06）。空气净化器使鼻结膜炎减少了52.2%，平均总症状评分（TSS）为1.6，而安慰剂组为3.3（p = 0.03）。与安慰剂相比，活性组的鼻炎反应有所改善（p = 0.03）。空气净化器将猫过敏原从79.6 ng/m³降至14.2 ng/m³。
在ALYATEC EEC中，空气净化器改善了猫过敏原暴露期间的临床过敏反应。
