Steuler H, Schröder B, Bürger H, Scholtissek C
Virus Res. 1985 Jul;3(1):35-40. doi: 10.1016/0168-1702(85)90039-5.
The nucleotide sequence of the nucleoprotein (NP) gene of the avian influenza A virus strain A/parrot/Ulster/73 (H7N1) has been determined. The gene (RNA segment 5) consists of 1565 bases. The only large open reading frame of the complementary RNA codes for a protein of 498 amino acids. A comparison of its sequence with that of three other influenza virus NPs shows that the NP of the parrot Ulster strain, although closely related to the NP of the other avian strain (A/FPV/Rostock/34), is definitely more closely related genetically to the NPs of the two human influenza strains, A/PR/8/34 and A/NT/60/68 than that of FPV. This raises the question how far the NP gene can cross the species barrier by reassortment and become adapted by mutation to the new host.
已确定甲型禽流感病毒A/鹦鹉/阿尔斯特/73（H7N1）株核蛋白（NP）基因的核苷酸序列。该基因（RNA片段5）由1565个碱基组成。互补RNA的唯一大开放阅读框编码一个498个氨基酸的蛋白质。将其序列与其他三种流感病毒NP的序列进行比较表明，鹦鹉阿尔斯特株的NP虽然与另一种禽株（A/FPV/罗斯托克/34）的NP密切相关，但在基因上与两种人类流感株A/PR/8/34和A/NT/60/68的NP的关系肯定比与FPV的NP更密切。这就提出了一个问题，即NP基因通过重配跨越物种屏障并通过突变适应新宿主的程度有多高。
